Words similar to rag
Example sentences for: rag
How can you use “rag” in a sentence? Here are some example sentences to help you improve your vocabulary:
Rag -/-mutants have a profound thymocyte development block at the TN3 to TN4/preDP transition [ 51 ] . During normal wild type fetal thymus development, significant DP cell development does not occur until E16.
Rag1 -/-fetal thymocytes have a stage-specific increase in proliferation relative to wild type
Therefore, the changes in proliferation seen in the fetal Rag mutant thymocytes reflect the earliest microenvironment changes occurring as a result of defective TEC-thymocyte interactions in the Rag -/-thymus.
There is considerable evidence that thymopoiesis differs in the fetal thymus during the initial creation of the microenvironment, as opposed to adult thymus function (reviewed in [ 47 ] ). Differences have been reported in responses to some cytokines, in signaling at the TN-DP transition in fetal compared to adult thymus, and in proliferation of CD4 +SP thymocytes [ 36 48 49 50 ] . The proliferation profiles of both wild type and Rag -/-fetal thymocytes support the hypothesis that fetal thymocyte maturation is fundamentally different from thymocyte development in the adult thymus.
In addition, the percentages of BrdU +cells in TN1 and TN2 subsets in the Rag1 -/-fetal thymus were significantly higher than those of the wild type adults (P < 0.001).