Words similar to pssm

Example sentences for: pssm

How can you use “pssm” in a sentence? Here are some example sentences to help you improve your vocabulary:

The non-redundant (NR) database of protein sequences (National Center for Biotechnology Information, NIH, Bethesda) was searched using the BLASTP program [ 100 ] . Position-specific scoring matrix (PSSM) searches were conducted using the PSI-BLAST program, typically with a PSSM inclusion expectation (E) value threshold of 0.01, and were iterated until convergence [ 100 101 ] . Prior to PSI-BLAST searches, query sequences were evaluated for compositional bias using the SEG program [ 102 ] . If no such bias was detected, searches were run with the composition-based statistics turned off, in order to maximize sensitivity [ 103 ] . Multiple alignments of protein sequence were constructed using the T_Coffee program [ 104 ] , followed by manual correction based on the PSI-BLAST results.
Additionally, a search of the NR database with a position-specific scoring matrix (PSSM) that included all unique RDRP and YRH sequences detected, with borderline E-values, a large protein from Corynebacterium glutamicum (Cgl1702), which also contained a DXDGD motif.
We were able to align the canonical RSS nonamer and Sb with this PSSM.
E -values less than 7. Thus, the PSSM was very effective at discriminating between GshA and non-GshA sequences in the database.
However, despite extensive comparisons using PSSM and careful visual examination, we failed to detect any residual sequence similarity between DDRP and RDRP, outside the core DPBB domain containing the metal-binding active site.