Words similar to pssm
Example sentences for: pssm
How can you use “pssm” in a sentence? Here are some example sentences to help you improve your vocabulary:
The PSSMs were prepared by choosing one or more starting queries (seeds) for a set of most frequently encountered domains (see reference [ 28] for details) and run against the NR database until convergence with the -C option of PSI-BLAST to save the PSSM.
However, despite extensive comparisons using PSSM and careful visual examination, we failed to detect any residual sequence similarity between DDRP and RDRP, outside the core DPBB domain containing the metal-binding active site.
The non-redundant (NR) database of protein sequences (National Center for Biotechnology Information, NIH, Bethesda) was searched using the BLASTP program [ 100 ] . Position-specific scoring matrix (PSSM) searches were conducted using the PSI-BLAST program, typically with a PSSM inclusion expectation (E) value threshold of 0.01, and were iterated until convergence [ 100 101 ] . Prior to PSI-BLAST searches, query sequences were evaluated for compositional bias using the SEG program [ 102 ] . If no such bias was detected, searches were run with the composition-based statistics turned off, in order to maximize sensitivity [ 103 ] . Multiple alignments of protein sequence were constructed using the T_Coffee program [ 104 ] , followed by manual correction based on the PSI-BLAST results.
This PSSM was more conserved than the 25-mer PSSM described above, with bits for all positions ranging from 0.2 to 1.9 and an average bits/position of 0.9 (Figure 5).
We were able to align the canonical RSS nonamer and Sb with this PSSM.
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