Words similar to protonatable
Example sentences for: protonatable
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As the number of protonatable nitrogens on the linear 22 kD ExGen 500 PEI polymer at physiological pH is roughly equal to 5.47 nmol per μg PEI, and 1 μg DNA corresponds to 3 nmol phosphate groups, this means that the peak yield observed was at a PEI nitrogen: DNA phosphate (N/P) ratio of ∼ 9. Thus, the most suitable N/P ratio for in vitro sympathetic neurons appears to be around 9, creating positively charged DNA/PEI complexes [ 17].
Another property of PEI that makes it suitable as a DNA vector is its structure, in which every third atom is a protonatable amino nitrogen that allows the polymer to function as an effective buffering system for the sudden decrease in pH from the extracellular environment to the endosomal/lysosomal compartment.