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Example sentences for: protomers

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Such analysis of the AAA protomers that are best conserved among organisms (AAA2, AAA3, AAA4 and AAA5 in midasin, and AAA1 in dynein) shows that the AAA protomers of midasin and dynein are substantially more closely related to each other than they are to those in the other branches of the AAA family examined (Figs 7, 8).
The overall alignment of the six AAA protomers in midasin from human, yeast and Giardia was created by first making separate alignment of the three organisms for each of the six AAA protomers.
There is no indication that any of these joining polypeptides contains a ATP-sensitive microtubule-binding site resembling that located between the AAA4 and AAA5 protomers of dynein [ 46 ] . The position of the N-terminal domain of midasin relative to the AAA domain is similar to that of the stem domain of dynein, and in several organisms the midasin N-terminal domain contains a cluster of basic residues that has the potential to bind microtubules in an ATP-insensitive manner.
In many cases, conformational changes occurring in the individual AAA protomers during an ATPase cycle function cooperatively to change the shape of the overall hexameric ring in a manner that exerts mechanical force on their protein or nucleic acid substrates.
The AAA domain of midasin, like that of dynein, contains six tandem copies of the amino acid sequence motifs that characterize AAA protomers (Fig.