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Example sentences for: protomers
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3; see also reference [ 5 ] ). The Walker A motif GxxxxGK [T,S] and Walker B motif hhhhDExx (where h is any hydrophobic residue and x is any residue), that contain residues essential for ATP binding and hydrolysis in all P-type ATPases [ 17 ] , are present in their canonical forms in the AAA2, AAA3, AAA4, and AAA5 protomers of midasin for all the organisms in Figure 3. The Walker A motif is present also in AAA1 and AAA6, although the Walker B motif in these protomers is deviant.
The AAA domain has been affected relatively little: all six AAA protomers are retained and the overall length of the domain is reduced by only ~19%.
The AAA domain of midasin, like that of dynein, contains six tandem copies of the amino acid sequence motifs that characterize AAA protomers (Fig.
Phylogenetic analysis of the sequence differences between the six protomers in the AAA-domain of midasin (Fig.
This analysis also indicates that the odd-numbered protomers, AAA3 and AAA5, and the even numbered protomers, AAA2, and AAA4, form two separate groups in which, regardless of the organism they come from, the members in any one group are more closely related to each other than they are to any members of the other group.