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Example sentences for: protomers
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There is no indication that any of these joining polypeptides contains a ATP-sensitive microtubule-binding site resembling that located between the AAA4 and AAA5 protomers of dynein [ 46 ] . The position of the N-terminal domain of midasin relative to the AAA domain is similar to that of the stem domain of dynein, and in several organisms the midasin N-terminal domain contains a cluster of basic residues that has the potential to bind microtubules in an ATP-insensitive manner.
In most AAA proteins, the ring structure is formed by six identical polypeptide subunits, with each contributing a single AAA protomer [ 14 ] . However, the AAA motor dynein differs in having six distinct AAA protomers disposed in tandem on a single polypeptide subunit of unusually high molecular weight, and it is believed to form a unimolecular pseudo-hexameric AAA ring [ 5 6 16 ] .
Phylogenetic analysis of the sequence differences between the six protomers in the AAA-domain of midasin (Fig.
These critical residues lie close to the γ-phosphate site in other AAA proteins with known structures and they are believed to trigger a change in the angle between the N- and C-subdomains of the protomer upon binding of ATP or dissociation of the γ-phosphate [ 18 ] . Indirect evidence suggests that such a conformational change in one protomer can be communicated to the adjacent protomers and result in a cooperative alteration in the shape of the overall hexameric ring [ 19 ] .
Only in the two outer protomers, AAA1 and AAA6, do the AAA sequence motifs depart sufficiently from their canonical forms to suggest that the protomers containing them play a less active role in midasin function.
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