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Example sentences for: prothrombin
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(6) Sepsis syndrome with disseminated intravascular coagulopathy (DIC) or coagulopathy required sepsis as defined in Appendix A in nosocomial events and DIC/coagulopathy defined as a drop in platelet count by 25% from baseline and an increase in prothrombin time (PT) or presence of fibrin degradation products.
As with the genotyping assays described above, Factor II prothrombin (FII) mutant genotyping results were also visualized either in real time or as an end-point assay (Figure 11).
However, despite association of the factor V G1691A (factor V Leiden) and prothrombin (factor II) G20210A mutations with venous thromboembolism and myocardial infarction [ 10 11 ] , neither mutation is strongly associated with risk of stroke [ 12 13 14 15 16 17 18 ] . Although a study of British adults found elevated levels of serum homocysteine to be associated with an increased risk of stroke [ 19 ] , a case-control study of a common polymorphism (methylenetetrahydrofolate reductase [MTHFR] T677C) that results in increased serum homocysteine concentrations found no difference between patients with stroke and controls in either genotype or allele frequency [ 20 ] . Because antiplatelet agents with different mechanisms of action can bring about significant reductions in stroke risk, several platelet receptor genes have been tested as candidate stroke susceptibility genes [ 21 22 ] . To date, however, no compelling evidence for an association between any platelet receptor gene polymorphism and risk of stroke has been found.
Presence of any of the following seven features, without an alternative cause, was required for satisfaction of the confirmatory criteria: ratio of partial arterial oxygen tension to inspired fractional oxygen below 280 (intubated) or 40% face mask in use (nonintubated); arterial pH below 7.30; urine output below 30 ml/h; systolic blood pressure below 90 mmHg or a fall in systolic blood pressure by more than 40 mmHg sustained for 2 hours despite fluid challenge; systemic vascular resistance below 800 dynes·s/cm 5; prothrombin time or partial thromboplastin time greater than normal or platelets below 100.
These include a significant decrease in blood pressure, a decrease in systemic vascular resistance, an increase in cardiac output, a decrease in pH, an increase in lactate, an increase in potassium, and a prolongation of prothrombin time [ 16, 17].
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