Words similar to prla
Example sentences for: prla
How can you use “prla” in a sentence? Here are some example sentences to help you improve your vocabulary:
Deletion of the signal sequence from phoA severely compromises export; export is restored in a prlA suppressor strain.
In the secY wild type strain, proofreading by SecE/Y would block export of LA57-N 102LT, while in the prlA4 strain, the PrlA4 suppressor would allow export of a portion of LA57-N 102LTto the periplasm.
The in vivo results are founded both on the co-immunoprecipitation experiments and on the fact that no export of the protein was detected in a prlA4 strain, while the in vitro results are based on the protease protection assays.
The PrlA (SecY) and PrlG (SecE) suppressors are compromised in their ability to proofread, allowing export of proteins with mutations, or even complete deletions, of the signal sequence.
In fact, all of the PrlA and PrlG suppressors are completely dependent on functional SecB for manifestation of suppressor activity [ 5 8 ] . Even certain proteins that are not normally SecB-dependent for translocation become SecB-dependent when they contain a signal sequence mutation and are exported via the suppressor pathway.