Words similar to pparγ
Example sentences for: pparγ
How can you use “pparγ” in a sentence? Here are some example sentences to help you improve your vocabulary:
504658 [http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=504658; and PPARγ (Hs.
PPARs are nuclear hormone receptors that are activated by micromolar concentrations of various FAs and FA analogues, such as fibrates and thiazolidinediones [ 29 ] . This subfamily can be divided into three isotypes, designated PPARα, PPARδ and PPARγ, each with tissue-specific expression.
While 15d-PGJ 2 is considered to be a PPARγ agonist, indomethacin and ibuprofen can activate both PPARγ and PPARα [ 27 ] . The following experiment was conducted to determine if a pure PPARα agonist, WY14643, could modulate the 25-OH-cholesterol induced cytotoxicity.
This finding is significant given prior reports that oxidative stress on RPE is an important contributing factor of age-related macular degeneration [ 5 42 ] . An earlier report also indicated that PPARγ agonists could prevent laser photocoagulation induced choroidal neovascularization in rat eyes and monkey eyes, which suggests the possible application of these agents on the exudative form of age-related macular degeneration [ 43 ] . It is important to note that the other PPARγ agonists tested in this study (ciglitazone, azelaoyl PAF and LY171883) were ineffective in saving cells under the same experimental conditions.
The PPARγ agonist, 15d-PGJ 2 , functions as a general inhibitor of microglial functions [ 56 57 58 ] . For example, this agent inhibits the expression of inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-1 β and major histocompatibility complex class II in activated microglia.
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