Example sentences for: positional

How can you use “positional” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our results indicate that comparative microsynteny-based mapping can facilitate positional cloning of a target gene when information on genomic location is limited.

  • As part of a positional cloning project, we became interested in a region of 5q31 between D5S393 and D5S2927.

  • Cell lines were created by incorporation of retroviral vectors into the genome and expression of Tag from either the retroviral LTR (considered to be a strong promoter) or the herpes virus thymidine kinase promoter, internal to the viral LTR [ 1 ] . In our established NIH 3T3 cell line, Tag is expressed from the htk promoter at considerably lower levels than from the LTR for a considerable time after transduction [unpublished observations, and [ 11 ] ]. However, when a large number of htk-Tag astrocyte clones were checked 100 days after creation, the expression levels displayed a very large range, and thus we expect that this weak promoter is subject to positional effects on transcription or mutational events that affect gene expression (unpublished data).

  • Objects in nuclei recognized by antibodies specific for phosphoprotein epitopes, cytoplasmic IFs, or both, have been reported in glial and neuronal cells, in situ and in vitro . The nuclear structures appear spherical or rod-like and may have a positional relationship with nuclear pores [ 1 2 3 4 ] . Morphologically, these structures appear similar to the nuclear "speckles" that are thought to be storage sites for RNA splicing factors [ 5 6 7 ] . However, while intermediate filament (IF) phosphoproteins could be components of nuclear speckles, they are immunologically distinct.

  • 13 suggested some positional effect variegation (PEV) of the transgene, an effect not previously reported in trangenes that include the entire CD2 LCR [ 17 18 ] . Further, we have noticed that the percentage of hCARΔcyt positive T cells in the line hCARΔcyt.CD2.


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