Words similar to polyketide
Example sentences for: polyketide
How can you use “polyketide” in a sentence? Here are some example sentences to help you improve your vocabulary:
Choices of the number and type of the building units are variables in determining polyketide structure.
Finally, the nascent carbon chain adopts different folding patterns after it leaves the PKS, and ‘tailoring’ enzymes can then add sugars or other chemical groups to it at many alternative positions, enabled by the pattern of chemical reactivity built into the polyketide by the PKS.
Polyketides are secondary metabolites (which give their producers a competitive advantage in their environment) produced mostly by bacteria and fungi and made by a complex and structurally diverse family of enzymes called polyketide synthases (see the primer by David Hopwood in this issue of PLoS Biology ). Among them are the anthracyclines, a group of anticancer drugs and antibacterials that includes tetracycline.
The model arose from the gene sequence, but was rapidly tested by mutating individual domains or adding or deleting whole modules and by observing predicted changes in the polyketide product.
(Hopwood 1999), was combined with chemical and biochemical experiments to begin to crack this ‘polyketide code’.