Example sentences for: polyketide

How can you use “polyketide” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The work also revealed fundamental mechanistic features of the polyketide synthases, Khosla says.

  • The model arose from the gene sequence, but was rapidly tested by mutating individual domains or adding or deleting whole modules and by observing predicted changes in the polyketide product.

  • Polyketides are secondary metabolites (which give their producers a competitive advantage in their environment) produced mostly by bacteria and fungi and made by a complex and structurally diverse family of enzymes called polyketide synthases (see the primer by David Hopwood in this issue of PLoS Biology ). Among them are the anthracyclines, a group of anticancer drugs and antibacterials that includes tetracycline.

  • The carbon chain of the polyketide would be assembled and modified progressively as the molecule moved along the protein, interacting with each domain in turn, which would select extender units, make carbon–carbon bonds, and modify keto groups as appropriate, depending on the presence or absence of domains for the three steps in the reductive cycle.

  • Another concerns the keto groups (C=O) that appear at every alternate carbon atom in the growing chain as a result of the condensation process (accounting for the name polyketide).


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