Words similar to polonies

Example sentences for: polonies

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It should be noted that polony amplification of genomic DNA from strains with equal p53 and K- ras 2 copy numbers, such as CAPAN-1, yielded equivalent numbers of p53 and K- RAS 2 polonies (data not shown).
As a result, polonies can be used to detect changes in gene copy number that arise due to either deletions or multiplications.
However, polonies seem well suited for this type of analysis since several hundred to several million [ 2 ] polonies for a particular gene can be analyzed on a single slide, thereby increasing the likelihood of detecting a rare event [ 22 ] . Additionally, the frequency of mutations can be readily determined using this approach due to the "digital" nature of polonies.
Prior to genotyping, the double stranded polonies were made single stranded by stripping away the non-acrydited strand in a two-step procedure [ 3 ] . The polony DNA was denatured by incubation in a formamide buffer (1x SSC, 70% formamide, 25% doubly deionized-water) at 70 C for 15 min.
One hallmark of cancer that can be readily observed using polonies is loss of heterozygosity (LOH).