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Example sentences for: pkcθ
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7), consistent with enhanced PKCα and PKCθ labeling in the NMJ [ 24 ] . Over a background of more diffuse staining, two stronger bands can be observed.
PKCβ was shown to localize to the presynaptic terminals of NMJs [ 22 23 ] , whereas PKCθ plays a postsynaptic role at the NMJ [ 24 ] . In skeletal muscle, PKCα was found in human muscle fibers [ 25 ] and with T-tubules in rabbit skeletal muscle [ 26 ] . However, it is unknown whether tethering to a PKC-anchoring protein mediates the localization to these compartments.
PKCβ labeling in the muscle fibers is faint, which corroborates the report that PKCα and PKCθ are the predominant PKC isoforms in skeletal muscle [ 24 ] , with PKCθ being more abundant in the membrane fraction of muscle and PKCα being more abundant in the cytosolic fraction.