Words similar to pkcγ

Example sentences for: pkcγ

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In situ hybridization revealed that PKCγ substrate neurogranin and vesicle-associated calcium/calmodulin binding protein (CAMK IV homolog) mRNA are both highly enriched in the superficial layers of the dorsal horn of the spinal cord (Fig.
3Aand 3B) whereas, PKCγ appears to be expressed in layer IIi of the dorsal horn (Fig.
2A), similar to PKCγ localization (Fig 3C).
Immunohistochemistry with antibodies against Galpha(olf), syntaxin 1A, and PKCγ revealed that these proteins are also enriched in the dorsal spinal cord (Fig.
Neurogranin has been shown to be phosphorylated by PKCγ, and this phosphorylation is greatly decreased in PKCγ knockout mice, suggesting neurogranin is a PKCγ-specific substrate [ 9 ] . Evidence that strongly suggests the phosphorylation of neurogranin plays an important role in neural plasticity comes from the studies that demonstrated neurogranin knockout mice show essentially the same deficits in behaviors related to learning and memory as that of the PKCγ knockout mice [ 10 ] . Neurogranin is not only a substrate of PKCγ, but also plays a important role in regulating PKC signaling [ 11 ] . Interstingly, PKCγ knockout mice demonstrate reduced neuropathic pain [ 12 ] . Similar to neurogranin, we found that a calmodulin-binding, vesicle-associated, CAM kinase IV-like protein is highly expressed and enriched in the superficial layer of the dorsal spinal cord.