Example sentences for: pkc-independent

How can you use “pkc-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The results indicate that in rat pancreatic β-cells, PMA modulates insulin secretion through a mixed mechanism: increases insulin secretion by activation of PKC, and meanwhile decrease insulin secretion by impairing β-cell excitability in a PKC-independent manner.

  • There are two possible explanations for the PKC-independent activation of K ATP by phorbol esters: 1) phorbol esters may increase K ATP activity in an intracellular ATP-independent manner and 2) phorbol esters may reduce sensitivity of K ATP to ATP.

  • These data indicate that PMA regulates insulin secretion mediated by a mixed mechanism, a PKC-dependent increase of insulin secretion and a PKC-independent decrease of insulin secretion.

  • The major and important finding in this study is that PMA impairs electrical excitation of rat pancreatic β-cells through PKC-independent mechanism.

  • 4panel D), suggesting that PMA increases K ATP -mediated currents in a PKC-independent manner.


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