Words similar to pkc-independent

Example sentences for: pkc-independent

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Phorbol esters are often used as activators of PKC to investigate the role of the kinase in cellular functions [ 1 ] . Accumulating lines of evidence indicates that PMA plays a complex role in regulation of cellular function, including PKC-dependent [ 18 19 20 ] and PKC-independent ways [ 23 24 21 ] . In the present results, PMA inhibited slow membrane depolarization and action potentials in response to glucose stimulation (Fig.
The major and important finding in this study is that PMA impairs electrical excitation of rat pancreatic β-cells through PKC-independent mechanism.
These data indicate that PMA regulates insulin secretion mediated by a mixed mechanism, a PKC-dependent increase of insulin secretion and a PKC-independent decrease of insulin secretion.
There are two possible explanations for the PKC-independent activation of K ATP by phorbol esters: 1) phorbol esters may increase K ATP activity in an intracellular ATP-independent manner and 2) phorbol esters may reduce sensitivity of K ATP to ATP.
In this regard, the present findings support the idea derived from previous findings on mouse [ 15 ] or obese-hyperglycaemic mouse β-cells [ 16 ] . However, PMA-induced PKC-independent hyperpolarization of β-cells was not previously reported [ 15 16 ] . The reason for the discrepancy is not clear at the moment.