Words similar to pkc-independent

Example sentences for: pkc-independent

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The major and important finding in this study is that PMA impairs electrical excitation of rat pancreatic β-cells through PKC-independent mechanism.
In this regard, the present findings support the idea derived from previous findings on mouse [ 15 ] or obese-hyperglycaemic mouse β-cells [ 16 ] . However, PMA-induced PKC-independent hyperpolarization of β-cells was not previously reported [ 15 16 ] . The reason for the discrepancy is not clear at the moment.
These results provide a novel insight of modulation mechanism of insulin secretion by PMA, increases insulin secretion by activation of PKC, and meanwhile decrease insulin secretion by impairing β-cell excitability in a PKC-independent manner in rat pancreatic β-cells.
Phorbol esters are often used as activators of PKC to investigate the role of the kinase in cellular functions [ 1 ] . Accumulating lines of evidence indicates that PMA plays a complex role in regulation of cellular function, including PKC-dependent [ 18 19 20 ] and PKC-independent ways [ 23 24 21 ] . In the present results, PMA inhibited slow membrane depolarization and action potentials in response to glucose stimulation (Fig.
The results indicate that in rat pancreatic β-cells, PMA modulates insulin secretion through a mixed mechanism: increases insulin secretion by activation of PKC, and meanwhile decrease insulin secretion by impairing β-cell excitability in a PKC-independent manner.