Words similar to pkc-independent

Example sentences for: pkc-independent

How can you use “pkc-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

There are two possible explanations for the PKC-independent activation of K ATP by phorbol esters: 1) phorbol esters may increase K ATP activity in an intracellular ATP-independent manner and 2) phorbol esters may reduce sensitivity of K ATP to ATP.
The results indicate that in rat pancreatic β-cells, PMA modulates insulin secretion through a mixed mechanism: increases insulin secretion by activation of PKC, and meanwhile decrease insulin secretion by impairing β-cell excitability in a PKC-independent manner.
In this regard, the present findings support the idea derived from previous findings on mouse [ 15 ] or obese-hyperglycaemic mouse β-cells [ 16 ] . However, PMA-induced PKC-independent hyperpolarization of β-cells was not previously reported [ 15 16 ] . The reason for the discrepancy is not clear at the moment.
These data indicate that PMA regulates insulin secretion mediated by a mixed mechanism, a PKC-dependent increase of insulin secretion and a PKC-independent decrease of insulin secretion.
These results provide a novel insight of modulation mechanism of insulin secretion by PMA, increases insulin secretion by activation of PKC, and meanwhile decrease insulin secretion by impairing β-cell excitability in a PKC-independent manner in rat pancreatic β-cells.