Words similar to pkc-independent

Example sentences for: pkc-independent

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There are two possible explanations for the PKC-independent activation of K ATP by phorbol esters: 1) phorbol esters may increase K ATP activity in an intracellular ATP-independent manner and 2) phorbol esters may reduce sensitivity of K ATP to ATP.
The results indicate that in rat pancreatic β-cells, PMA modulates insulin secretion through a mixed mechanism: increases insulin secretion by activation of PKC, and meanwhile decrease insulin secretion by impairing β-cell excitability in a PKC-independent manner.
Phorbol esters are often used as activators of PKC to investigate the role of the kinase in cellular functions [ 1 ] . Accumulating lines of evidence indicates that PMA plays a complex role in regulation of cellular function, including PKC-dependent [ 18 19 20 ] and PKC-independent ways [ 23 24 21 ] . In the present results, PMA inhibited slow membrane depolarization and action potentials in response to glucose stimulation (Fig.
These data indicate that PMA regulates insulin secretion mediated by a mixed mechanism, a PKC-dependent increase of insulin secretion and a PKC-independent decrease of insulin secretion.
The major and important finding in this study is that PMA impairs electrical excitation of rat pancreatic β-cells through PKC-independent mechanism.