Words similar to pkc-dependent

Example sentences for: pkc-dependent

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These data indicate that PMA regulates insulin secretion mediated by a mixed mechanism, a PKC-dependent increase of insulin secretion and a PKC-independent decrease of insulin secretion.
Phorbol esters are often used as activators of PKC to investigate the role of the kinase in cellular functions [ 1 ] . Accumulating lines of evidence indicates that PMA plays a complex role in regulation of cellular function, including PKC-dependent [ 18 19 20 ] and PKC-independent ways [ 23 24 21 ] . In the present results, PMA inhibited slow membrane depolarization and action potentials in response to glucose stimulation (Fig.
The second set of observations indicate that reactive oxygen species (ROS) activate PLD2 in a PKC-dependent manner [ 9 ] . There is much evidence that ROS generation is upregulated in AD brain [ 42 ] . Thus, it is possible that PLD2 may be activated in this disease resulting, perhaps, in dysregulation of PC metabolism.
There are multiple neurotransmitters whose receptors are coupled to PKC-dependent activation of PLD [ 7 ] , and thus this mode of regulating the availability of choline for ACh synthesis is likely to be widespread.
Recently, we reported that phorbol ester inhibited Ca 2+influx through PKC-dependent and PKC-independent pathways [ 21 ] . In the present study, we further evaluated the non-PKC mechanism of PMA action on β-cell electrical excitation by using patch-clamp techniques.