Example sentences for: phytoestrogens

How can you use “phytoestrogens” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The results of this study showed that phytoestrogen concentrations vary widely among diets (between 200 μg/g and 600 μg/g of phytoestrogens).

  • These results are presented in figure 7. This suggests that high levels of dietary phytoestrogens significantly increased the abundance of COX-2 in the male rat frontal cortex.

  • In a separate study, in complete opposition to experiment 1 (in experiment 2), phytoestrogens, within diet, significantly altered acquisition of the maze in females.

  • The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.

  • Dietary phytoestrogens sex reversed VSM, as expressed in the radial-arm maze by enhancing spatial memory in females but inhibited this ability in males, this finding corresponds to research regarding increased dementia observed in aged men consuming high tofu levels [ 44 ] . However, while it is important to establish the influence of dietary phytoestrogens on brain function and behavior in animal models, the true significance in humans remains to be determined as it relates to the present findings.


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