Example sentences for: phytoestrogen

How can you use “phytoestrogen” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Upon arrival all animals were allowed ad libitum access to either a commercially available diet with high phytoestrogen levels (Harlan Teklad Rodent Diet 8604, Madison, WI, USA) containing 600 micrograms of phytoestrogens/gram of diet; referred to hereafter as the Phyto-600 diet, or a custom phytoestrogen-free diet; referred to hereafter as the Phyto-free diet, obtained from Ziegler Bros. (Gardner, PA, USA) and water.

  • Following the eight-arm task the animals in experiments 1 and 2 were sacrificed and blood was taken to determine circulating phytoestrogen levels and brain samples were collected for CALB and COX-2 determination.

  • Helix Pomatia enzyme was purified with activated charcoal and used for enzymatic hydrolysis of the phytoestrogen conjugates.

  • The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.

  • Phyto-free fed males where there is an abundance of ER-β receptors [ 2 ] , while phytoestrogen levels were similar in these animals in the hippocampal region.


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast