Words similar to phosphodiesterase
Example sentences for: phosphodiesterase
How can you use “phosphodiesterase” in a sentence? Here are some example sentences to help you improve your vocabulary:
Members of the DNase 1, LINE-1 repeats, inositol 5'-polyphosphate phosphatase, Nocturnin, CCR4, cytolethal distending toxin, neutral sphingomyelin phosphodiesterase, and amino acid methyltransferase families were found with expectation values of 10 -4or less to be significantly similar to APE1.
On the other hand, it has been previously demonstrated that direct activation of adenylate cyclase by Forskolin or cholera toxin, inhibition of cAMP-specific phosphodiesterase, and treatment with a cell permeable cAMP analog, induces a rise in intracellular cAMP [ 22 23 24 25 26 ] . Since cAMP is known to modulate the expression of CD8 in mice [ 27 ] , we sought to determine whether cAMP-dependent protein kinase (PKA)-mediated signaling plays a role in modulating the mRNA levels of CD3, CD4, and CD8 in ex vivo examined human thymocytes.
Total post-Ficoll un-fractionated thymocytes were incubated in the presence or the absence of 10 nM PMA and/or 0.1 mM cAMP + 1 mM of the phosphodiesterase inhibitor isobutylemthylxnthine (IBMX).
To each well, phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) was added to a final concentration of 100 μM, followed by addition of agonists at different concentrations and incubation at 37°C.
Thus, only 9 genes were newly identified as IL-2-induced immediate/early T cell genes; including the signaling proteins SLP76 and RGS1, the transcription factors IRF4 and XBP1, and 5 miscellaneous genes (DKFZp586F1323, mitofilin, cAMP-specific phosphodiesterase 4B, CMP-N-acetylneuraminate monooxygenase, and the aryl hydrocarbon receptor).
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