Words similar to phagosomes
Example sentences for: phagosomes
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Mycobacteria enter macrophages primarily by conventional receptor-mediated phagocytic pathways [ 3 ] . Following phagocytosis, phagosomes containing viable tubercle bacilli fail to acidify, apparently because of failure to insert a proton-ATPase pump into the phagosomal membrane [ 4 5 6 ] . This leads to altered vacuolar maturation such that phagosome-lysosome fusion is blocked and the mycobacteria-containing vacuoles end up with an internal pH of about 6 and markers of phagosomes and early and late endosomes [ 7 8 9 10 11 ] . The mycobacterial genes responsible for these processes are largely unknown.
Likewise, M. tuberculosis and M. avium appear to remain in distinct phagosomes that do not harbor more than one bacilli per vacuole (see Figures 1Aand 4Bin [ 38 ] for example).