Words similar to pgc-
Example sentences for: pgc-
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The inhibitory action of 4-AP on progesterone production was investigated further using not only primary cultures, but also the spontaneously established granulosa cell line, PGC-2 [ 19 ] . Although PGC-2 lack FSH receptors, these cells can serve as a useful in vitro model for GC function, because they produce cAMP in response to forskolin and synthesize progesterone and estradiol when supplied with appropriate substrates.
To ensure the validity of this model for assessing the functional effects on the K +channel antagonists, we used whole-cell patch clamp techniques [ 4 ] to document the presence of 4-AP sensitive K +currents in PGC-2 (see additional file 1).
Other NR coactivators include TRAP220 [ 7 ] , which is part of a larger complex (TRAP/DRIP/SMCC/mediator) that contacts the basal transcription machinery and PGC-1 [ 8 ] , a cold inducible coactivator that binds CBP and SRC-1 and proteins involved in RNA processing [ 9 ] . NR corepressors include NR corepressor (N-CoR) and silencing mediator of retinoid and thyroid responsive transcription (SMRT) [ 4 ] . Both N-CoR and SMRT repress transcription, at least in part, by binding to histone de-acetylases (HDACs) either directly or indirectly through other corepressor complex components.
In contrast, 4-AP significantly reduced estradiol production by PGC-2 cultures provided with androstenedione (Figure 4B).
To this end, we treated primary cultures of GC and monolayers of the immortalized granulosa cell line PGC-2 [ 19 ] with the K +channel antagonist 4-aminopyridine (4-AP).
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