Words similar to pgc-
Example sentences for: pgc-
How can you use “pgc-” in a sentence? Here are some example sentences to help you improve your vocabulary:
The inhibitory action of 4-AP on progesterone production was investigated further using not only primary cultures, but also the spontaneously established granulosa cell line, PGC-2 [ 19 ] . Although PGC-2 lack FSH receptors, these cells can serve as a useful in vitro model for GC function, because they produce cAMP in response to forskolin and synthesize progesterone and estradiol when supplied with appropriate substrates.
However, there may be cause for some optimism for the average mortal, since endurance exercise training in healthy humans leads to fiber-type specific increases in the abundance of PGC-1 and PPAR-α protein in skeletal muscle (Russell et al.
PGC-2 cells were provided by B.R.
Other NR coactivators include TRAP220 [ 7 ] , which is part of a larger complex (TRAP/DRIP/SMCC/mediator) that contacts the basal transcription machinery and PGC-1 [ 8 ] , a cold inducible coactivator that binds CBP and SRC-1 and proteins involved in RNA processing [ 9 ] . NR corepressors include NR corepressor (N-CoR) and silencing mediator of retinoid and thyroid responsive transcription (SMRT) [ 4 ] . Both N-CoR and SMRT repress transcription, at least in part, by binding to histone de-acetylases (HDACs) either directly or indirectly through other corepressor complex components.
The PGC-1 related protein PERC also binds ERα preferentially, and potentiates ERα activity more strongly than that of ERβ [ 38 ] . We recently observed that ERα binds the C-terminal NR interacting regions of N-CoR and SMRT in the presence of SERMs but not estrogens [ 39 ] . In this study, we report that ERβ interactions with N-CoR and SMRT are promoted by agonists and inhibited by SERMs.
Loading...