Words similar to peripubertal
Example sentences for: peripubertal
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The evidence that adolescent diet may affect the risk of breast cancer derives from several lines of evidence [ 1 ] . Rates of breast cancer among Asian immigrants to the United States do not approach those of US white women until the second or third generation, suggesting that exposures during childhood and adolescence are important in establishing a higher risk of breast cancer [ 2 3 ] . Norwegian women who were adolescents during World War II, when average caloric intake decreased by 22%, have a reduced incidence of breast cancer, suggesting that energy restriction might affect risk [ 4 ] . Similarly, in animal models, energy restriction in the peripubertal period inhibits mammary tissue proliferation and reduces the subsequent risk of mammary tumors [ 5 6 ] . Exposure of rats to carcinogens before first pregnancy increases the incidence of mammary tumors compared with exposure after first pregnancy [ 7 ] . After differentiation of the mammary gland at the time of first full-term pregnancy of the rat, the rate of cell division decreases and length of the cell cycle increases, allowing more time for DNA repair [ 8 ] . This biologic phenomenon might explain the apparent vulnerability of the adolescent breast tissue to carcinogenic exposures.
In contrast, SD had a greater effect on testis size in peripubertal males (55% smaller testis volume in SD than LD; Fig 3) than in adult males (15% smaller testis volume in SD than LD; Fig.
6), indicating that adults and peripubertal young rats have similar non-reproductive responses to SD.
2), similar to those in peripubertal young rats in SD (e.g.
Recent reports have documented variability in photoresponsiveness in peripubertal males among laboratory rat strains [ 5 6 ] . The fact that photoresponsiveness extends to adulthood in F344 rats suggests that genetic variation in the presence and strength of adult photoresponsiveness is present among rat strains.
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