Words similar to peptide-based
Example sentences for: peptide-based
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DNA- and peptide-based vaccines have become popular due to the comparative ease of construction, the circumvention of potential safety issues around attenuated organisms, and for their potentially enhanced immunogenicity compared to heat-killed and subunit vaccines [ 20 21 22 ] . DNA vaccines have the added attraction of efficiently priming both humoral and cytotoxic cell responses, a property largely lacking in subunit and attenuated organism vaccines.
Multiple antigen peptide vaccines can also be designed to contain T and B epitope regions from numerous protein antigens derived from a complex infectious agent which could therefore confer broad protection without the potential dangers of an attenuated whole organism vaccine [ 16 ] . However, it is of note that occasionally a well-designed peptide-based vaccine can elicit strong antibody responses to the synthetic immunogen that do not confer protection from the parasite to which they were originally designed [ 23 ] . This may be due to either the induction of an inappropriate antibody isotype in the mouse strain used, or to an inadequate overall response.
Pyochelin from Pseudomonas aeruginosa exemplifies an iron siderophore whose peptide-based synthesis depends on CoA-activated salicylate (closely related to anthranilate) as a starter unit [ 36].