Words similar to pcd
Example sentences for: pcd
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This plasmid, called pCD1 [ 1 ] in Y. pestis , encodes for a type III secretion apparatus necessary for the translocation of effector proteins (Yops) into eukaryotic target cells [ 2 ] . The net result of this polarized toxin translocation is the disruption of eukaryotic cell signalling and structure [ 2 ] . Induction of the virulence-related genes on pCD1 is linked to an in vitro phenomenon termed the Low Calcium Response (LCR).
MAP kinases (Mitogen-Activated Protein kinases) have very important roles in PCD.
These compounds can activate some nuclear receptors including steroidogenic factor 1 [ 44 ] and LXR, which may be partially responsible for their biological activities [ 45 46 ] . Cholesterol oxides are inhibitors of HMG-CoA reductase, the key enzyme of cholesterol biosynthesis pathway [ 47 ] . The ability to bind to an intracellular receptor, oxysterol binding protein, may be responsible for their inhibition of cholesterol biosynthesis [ 48 49 ] . It should be noted that addition of cholesterol does not prevent cholesterol oxide induced cell death, which leads to the suggestion that inhibition of cholesterol synthesis is not the cause of cholesterol oxide induced PCD [ 50 51 ] . The critical events that result in cholesterol oxide induced cytotoxicity remain to be determined.
Our EM and fluorescent PCD assays included three (P10, P14 and P18) and four (P10, P12, P14 and P18) time points respectively during this critical period.
Given the suggestion that an up-regulation of c-jun is a cause of PCD [ 15 16 ] , a reduction in c-jun activation by PPAR agonists should attenuate 25-OH-cholesterol induced cytotoxicity.
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