Example sentences for: pai-

How can you use “pai-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The second-order rate constants (in M -1s -1units) of the fibrosarcoma PAI-1 and the wtPAI-1 towards t-PA were 1.4 ± 0.5 × 10 7and 1.7 ± 0.6 × 10 7, and towards uPA were 4.1 ± 1.4 × 10 7and 4.4 ± 1.6 × 10 7, respectively.

  • The variable region in serine proteases domain determines their specificity for PAI-1.

  • The resultant pVL1393-PAI-1 was analyzed by restriction mapping and sequencing.

  • An inhibitory effect of USF on Myc-mediated cellular proliferation has been demonstrated in HeLa cells [ 33 ] , and a non-canonical HLH element inhibits expression of the fibroblast growth factor binding protein (FGF-BP) in several carcinoma cells [ 34 ] . Furthermore, USF2 inhibits binding of hypoxia-inducible factor-1 (HIF-1) to the plasminogen activator inhibitor -1 (PAI-1) gene in hepatocytes in order to disturb transcriptional activation [ 35 ] . Our results add C/EBPβ-mediated activation of RIIβ to the mechanisms inhibited by USF.

  • Fast TGFβ responder genes, such as smad7 , whose maximum activation by TGFβ was reached after 60 min, was only slightly affected by SB-203580, while slow responders, such as pai-1, pthrp or upa , that showed peak activation after 180-240 min, were very sensitive to the repressive effect of SB-203580.


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