Example sentences for: pai-

How can you use “pai-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Breast cancer cells frequently metastasize to bone causing bone destruction and hypercalcemia [ 9 ] . Parathyroid hormone-related protein (PTHrP), secreted by these cells, is a major mediator of the osteolytic process [ 10 ] . Osteolysis leads to the release of TGFβ which, in turn, further induces PTHrP expression [ 11 ] . Other tumor-relevant genes, such as pai-1 or upa , can also be activated by TGFβ.

  • Inhibition of thrombin and plasmin by PAI-1s

  • More importantly, Glu351 of PAI-1 is a specificity determinant for uPA, thrombin and plasmin, but not for tPA.

  • To elucidate the mechanism through which such mutations affect the activity of PAI-1, we determined their effect on the functional stability of PAI-1 and on its ability to form an SDS stable complex with either tPA or uPA.

  • Mutant of Pro357Gly blocked the inhibitory activity of PAI-1 (Fig.


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