Words similar to pai-

Example sentences for: pai-

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We have previously demonstrated that TGFβ upregulates PTHrP and PAI-1 RNA levels in MDA-MB-231 cells [ 19 ] . TGFβ affected PTHrP expression primarily by increasing the level of the promoter P3-specific transcript [ 19 ] . Quantitative PCR analysis using primers allowing the detection of PTHrP P3 and PAI-1 transcripts indicated that incubation of MDA-MB-231 cells with SB-202190 and SB-203580 greatly inhibited TGFβ-induced increase in PTHrP and, to a lesser extent, PAI-1 mRNA levels (Fig.
Asp355His, Asp355Lys, Asp355Glu, Asp355Gln and Asp355Asn were prepared and used to show that the negatively charged aspartic acid in PAI-1 is essential (though not sufficient) for its inhibitory activity.
PAI-1 shares a 35% homology with 40 other serpins.
In addition, it is known that PAI-1 inhibits either tPA or uPA by forming a 1:1 SDS stable complex [ 4 ] , wtPAI-1 indeed could form SDS stable complex with tPA or uPA (Fig.
The pPAI-1-AI was digested with EcoRI and BglII to release a 1426 basepair (bp) PAI-1 coding sequence, which was isolated, purified, and ligated into EcoRI and BglII digested pVL1393.