Example sentences for: over-expression

How can you use “over-expression” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To verify over-expression of the ATPase 6 gene in rat lung tissue, in situ hybridization with digoxigenin-labeled riboprobes was performed.

  • Over-expression of PDGFR has been reported in a variety of human tumors including glioma and glioblastoma, pancreatic and colonic cancers, breast, bone and ovarian tumors [ 11 ] . In normal cells, expression of PDGFR can be seen in the fibroblasts and the smooth muscle cells in the lung and airway [ 12 ] . There is so far to our knowledge no report to link the expression of PDGFR to lung cancer.

  • It also remains to be determined whether over-expression of the ATPase 6 gene is specific for P. carinii infection.

  • It has been shown that engineered over-expression of wild-type p53 in vitro causes inhibition of MGMT transcription in human tumor cells [ 29 ] . Abundant over-expression of wild-type p53, owing to their stage of origin, is a characteristic feature of GCTs [ 30 ] . A possibility also exists that the MGMT expression may, in general, be down regulated in tumors arising from embryonic-type cells.

  • Systemic and local delivery of an adenovirus encoding ATF have been shown to inhibit the growth of primary tumour implants as well as of tumour metastasis in different animal models [ 18 19 ] . In the ATF-BPTI chimeric protein, ATF has two functions (1) the anti uPA effect with its known angiostatic activity and (2) delivery of BPTI at the tumour site due to over-expression of uPAR on tumour and endothelial cells.


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