Example sentences for: over-expression

How can you use “over-expression” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Using a cDNA fragment identical to the PAC-1 probe on the cDNA microarray, we performed a Northern blot analysis and confirmed the over-expression of two transcripts in leukemic LGL cells (Fig.

  • Over-expression of homeodomain-interacting protein kinase 2 (HIPK2), which increases p53 protein expression and/or stability, leads to a downregulation of mdm2 protein, but not mRNA [ 29 ] . Consequently, the RU486-induced increase in mdm2 mRNA expression, coupled with a decrease in that of P53, may also act in tandem to suppress the liver apoptotic capacity (Fig 1B).

  • These results are also consistent with the possibility that the primary defect in sα i2 is a reduced ability to interact with βγ; Gα containing mutations in known sites of contact with βγ fail to localize to PM, but over-expression of βγ can rescue their PM localization [ 28 29 ] . However, the crystal structures [ 30 31 ] show that the C-terminal β6-α5 loop/α5 helix region does not directly contact βγ.

  • However, by using gene-specific probes in an RNase protection assay, we were able to demonstrate the over-expression of granzyme B and granzyme H separately in leukemic LGL cells (Fig.

  • Another assumption of the I-TRAP approach is that over-expression of a transcriptional regulator will be sufficient to induce gene expression from its regulated promoters.


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