Words similar to over-expression
Example sentences for: over-expression
How can you use “over-expression” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, through the use of STAT5-/- mice, Ihle et al have been able to identify those IL-2 target genes that require STAT5 [ 56 57 ] . Similar approaches with mutant signaling proteins, knockouts, or over-expression systems enable such dissection of the signal transduction pathways leading to specific target genes.
The following results support this hypothesis: 1) sα i2 and α i2 are equally labeled by a pulse of 3H-myristate, although much less sα i2 protein is detected; 2) sα i2 displays a propensity to localize to potential aggresome-like structures, and this localization is greatly enhanced by proteasome inhibitor treatment; 3) the α i2 A327S mutant, previously shown to be unstable and defective in guanine-nucleotide binding, shows a similar pattern of subcellular localization ( i.e., intracellular membranes rather than PM); 4) βγ over-expression increases expression of sα i2 and promotes PM localization of sα i2 and α i2 A327S, but βγ co-expression does not prevent sα i2 localization to potential aggresome-like structures when cells are treated with proteasome inhibitors; and 5) pulse-chase analysis indicates that sα i2 is rapidly degraded.
Large-scale over-expression and purification of the mutants showed that both mutants were isolatable at levels comparable to that of wild-type L1.
The stable nucleolar localization of BLM is not due to over-expression but rather to a function encoded in the C-terminus of BLM.
Previous studies from our laboratory have consistently demonstrated loss of the SpeB phenotype in S. pyogenes isolates injected in a skin air sac and recovered from the organs of lethally infected mice [ 10 16 ] . This selection was not associated with loss of β-hemolysis but was associated with over-expression of M and M-related proteins, which in turn are predictive of the invasive potential of the organism in a skin infection model [ 16 ] . Based on the phenotypic characteristics of the kidney-recovered variant (β-hemolytic positive, M and M-related protein positive and SpeB negative) we predicted that this variant would be as virulent or more virulent than the wild type organism in the mouse skin infection model.
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