Words similar to orphan
Example sentences for: orphan
How can you use “orphan” in a sentence? Here are some example sentences to help you improve your vocabulary:
Until recently, LC-PUFA effects on gene transcription were thought primarily to be mediated by a single subfamily of orphan nuclear receptors - peroxisome proliferator activated receptors (PPARs); however, it is now becoming evident that FAs can affect many different genes either via direct interactions or indirectly through additional transcription factors including hepatic nuclear-4α (HNF-4α), nuclear factor κβ (NF-κβ), retinoid X receptor α (RXRα), sterol regulatory element binding protein-1c (SREBP-1c), and liver X receptors (LXRα and LXRβ) [ 17 ] . Indeed, the enthusiasm for uncovering the biological pathways underlying the beneficial actions of LC-PUFA has revealed a story that is increasingly more complex than originally supposed [ 23 ] , thereby making microarray technology an ideal platform to further decipher the many roles of these nutritional lipids.
Innovative financing mechanisms must be considered to produce this orphan biologic.
Tie1 is an orphan receptor, whereas the ligands of Tie2 receptor have been identified as angiopoietin (Ang)-1 and Ang-2 [ 5 6 ] . Ang-1 has been shown to be responsible for recruiting and sustaining periendothelial support cells [ 7 ] . It has been reported that Ang-2 disrupts blood vessel formation in the developing embryo by antagonizing Ang-1-induced autophosphorylation of Tie2 [ 6 ] . Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence of remodeling and sprouting of blood vessels [ 7 8 ] . The physiologic roles of the Tie2 receptor and its ligands are limited to angiogenic processes that occur subsequently to the earlier vasculogenic and angiogenic actions of vascular endothelial growth factor (VEGF) and its receptors [ 7 ] . VEGF and the Tie family orchestrate optimal blood vessel formation [ 9 10 ] .
Moreover, Alimi et al . [ 21 ] have shown that at least some of the orphan genes in E. coli are indeed transcribed.
18: Rebel Without a Lollipop --Confused, rebellious teen (James Dean) receives life lesson from poor orphan girl (Shirley Temple); the teen's later, tragic death inspires girl to life in foreign service.
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