Words similar to orphan
Example sentences for: orphan
How can you use “orphan” in a sentence? Here are some example sentences to help you improve your vocabulary:
This approach might help to inform the development of business models for the production and distribution of orphan biologics for other neglected diseases.
Michael Caine's turn as the benign head of the orphanage (a doctor addicted to ether) is excellent, but Tobey Maguire, playing the orphan Caine takes under his wing and grooms to be his successor, is too deadpan for most critics.
Schlichtmann doesn't take this "orphan" case--brought by the parents of several children who died of leukemia--because he wants to do good but because he figures that Grace and Beatrice will fork over huge sums of money to keep the parents from testifying publicly about their children's last days.
18: Rebel Without a Lollipop --Confused, rebellious teen (James Dean) receives life lesson from poor orphan girl (Shirley Temple); the teen's later, tragic death inspires girl to life in foreign service.
The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.
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