Words similar to orphan
Example sentences for: orphan
How can you use “orphan” in a sentence? Here are some example sentences to help you improve your vocabulary:
Innovative financing mechanisms must be considered to produce this orphan biologic.
Schlichtmann doesn't take this "orphan" case--brought by the parents of several children who died of leukemia--because he wants to do good but because he figures that Grace and Beatrice will fork over huge sums of money to keep the parents from testifying publicly about their children's last days.
This approach might help to inform the development of business models for the production and distribution of orphan biologics for other neglected diseases.
The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.
But Hughes must have realized his mistake, because the next year he essentially rewrote it as Some Kind of Wonderful . The quirky and talented poor kid, played by Eric Stoltz, has a crush on the prom queen, which breaks the heart of the orphan girl (!) who has been secretly infatuated with him for years.
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