Example sentences for: orphan

How can you use “orphan” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • If this interpretation is correct, our results confirm those of Schmid and co-workers [ 34, 59] who have shown that a large fraction of randomly sampled coding sequences and orphan genes are rapidly evolving in the genus Drosophila . Our results are also consistent with those of Ashburner et al . [ 60] who show that genes with known mutant phenotypes in D. melanogaster are more likely to have a conserved homolog in GenBank relative to predicted genes with no known phenotype.

  • Starr pressured Kathleen Willey's friend Julie Hiatt Steele by questioning the legality of her adoption of a Romanian orphan.

  • The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.

  • 18: Rebel Without a Lollipop --Confused, rebellious teen (James Dean) receives life lesson from poor orphan girl (Shirley Temple); the teen's later, tragic death inspires girl to life in foreign service.

  • This approach might help to inform the development of business models for the production and distribution of orphan biologics for other neglected diseases.

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