Example sentences for: orphan

How can you use “orphan” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.

  • Similarly, Zdobnov et al . [ 23] show that D. melanogaster orphan genes tend to exhibit lower levels of conservation in pairwise comparison with A. gambiae [ 23].

  • The owner, a member of one of Cuba’s most important families, rescued orphan girls and took them into his home — his obra pía (work of piety) that lends its name to both the house and its street.

  • 18: Rebel Without a Lollipop --Confused, rebellious teen (James Dean) receives life lesson from poor orphan girl (Shirley Temple); the teen's later, tragic death inspires girl to life in foreign service.

  • “Chutzpa is that quality enshrined in a man, who, having killed his mother and father, throws himself on the mercy of the court because he is an orphan.


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