Words similar to opioids
Example sentences for: opioids
How can you use “opioids” in a sentence? Here are some example sentences to help you improve your vocabulary:
Many physicians misperceive that respiratory depression is a significant risk when prescribing opioids for pain.
Clinical trials in acute pain normally last four to six hours, because that is the duration of effect for most analgesics, whether injected or as tablets, and for simple analgesics, NSAIDs or opioids.
Our laboratory has previously reported [ 11 13 ] that 5-opioids induce tyrosine phosphorylation of the δ-OR, and it appears that this is catalyzed by the non-receptor tyrosine kinase Src.
In the presence of the EGFR, ligand activation of LPA and ET-1 receptors did not increase EGFR phosphorylation even though both the LPA and ET-1 receptors stimulated ERK activity by 10-fold over basal [ 27 ] . Specifically, key protein intermediates may be physically associated with endogenous RTKs in HEK-293 cells, and therefore, down-regulation of the EGFR may negatively affect ERK phosphorylation by opioids.
It has been postulated that activation of these kinases allows GPCR agonists to modulate such diverse molecular events as cell proliferation, differentiation, and survival [ 1 ] . To date, all three cloned opioid receptor types (μ,δ, κ) and the closely related nociceptin receptor have demonstrated the ability to signal through their heterotrimeric G proteins (G i or G o ) to at least one type of MAPK [ 2 3 4 ] . Among the members of this family that are activated by opioids, are the two extracellular signal-regulated protein kinases (p44 MAPK(ERK 1) and p42 MAPK(ERK 2)) [ 5 ] and the p38 protein kinase [ 3 ] . However, the precise mechanism by which OR stimulation produces an increase in MAPK activity is still unknown and under investigation.
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