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Example sentences for: opossum
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Modification of the EESSTSE to EESSVAE was sufficient to prevent down-regulation of the opossum alpha-2C adrenergic receptor.
The opossum alpha-2C adrenergic receptor has a very similar acidic serine motif (EESSTSE) in the third intracellular loop (Figure 1; [ 21 ] ), whereas the human alpha-2C receptor has a DESSAAAE sequence in the same region (Figure 2; [ 22 ] ). Thus, we postulated that the lack of down-regulation in the human alpha-2C was related to having only two rather than four serines in the motif, and furthermore that the ability of the opossum alpha-2C to undergo down-regulation was dependent on having all four serine/threonine residues in the EESSTSE motif.
Females lack an estrous cycle and anestrous adults are dependent upon direct contact with a non-volatile male pheromone for induction of estrus [ 8 ] . Hormonal control of scentmarking and sexual behavior of this species (hereinafter, opossum) has been described in some detail [ 9 10 ] . Estrus is induced when females nuzzle scentmarks from the androgen-dependent suprasternal (chest) gland [ 10 11 ] . Nuzzling delivers nonvolatile chemical signals to the vomeronasal organ (VNO) [ 12 ] and surgical removal of the VNO prevents induction of estrus by scentmarks alone [ 13 ] , although cautery ablation of the VNO fails to prevent ovarian activation and ovulation in females that are caged with adult males [ 14 ] . While anestrous adults are reliant on male pheromone for reproductive activation, spontaneous postlactational estrus occurs in the absence of direct contact with male pheromone [ 15 ] .
The elimination of the terminal two hydroxyl amino acid residues in the EESSTSE motif is sufficient to prevent down-regulation of the opossum alpha-2C adrenergic receptor.
In addition to the hydroxyl amino acid residues, acidic residues may also be an important sequence element for alpha-2 adrenergic receptor phosphorylation and regulation [ 27 28 ] . The region from 300 to 313 in the opossum alpha-2C receptor, which encompasses the EESSTSE motif, is a high acidic region, with 50% (seven of fourteen) of the residues being acidic amino acids (Figure 2).
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