Words similar to nucleic-acid-binding
Example sentences for: nucleic-acid-binding
How can you use “nucleic-acid-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
Of these, four subunits, which correspond to the bacterial α, β, β' and ω, are universally present in all cellular DDRPs and constitute the conserved DDRP core [ 7 ] . Orthologs of the β and β' subunits are also encoded in the genomes of several families of large eukaryotic DNA viruses [ 33 34 35 ] . Biochemical studies have shown that the catalytic site of DDRP resides in the β' subunit and contains three invariant aspartates that coordinate a Mg 2+cation [ 22 23 24 36 ] . Recent structural analyses demonstrated that the core of DDRP is assembled around the β and β' subunits, which interact with each other to form a positively charged nucleic-acid-binding cleft.
Thus, it appears plausible that these domains evolved from an ancestral nucleic-acid-binding module that, on one hand, gave rise to the nucleases through the acquisition of an amino-terminal helical extension that provided the active site, and on the other hand, diversified into distinct nucleic-acid-binding domains.
Based on the crystal structure, it has been proposed that the region containing the Zn ribbon may interact with the promoter during transcription initiation in bacteria [ 23 ] . Hence, it is plausible that a nucleic-acid-binding Zn-ribbon had been recruited to the ancestral polymerase core, which consisted of the DPBB domains, and contributed to non-specific interactions with the template.
Nevertheless, the extended similarity between the YRH and RDRP sequences and the presence of potential nucleic-acid-binding modules, such as a C-terminal Zn-ribbon in the SpβC2 YonO protein, suggest that the YRH proteins also have a RNA polymerase activity.
At least the former, and perhaps even the latter, appear to belong to a large class of nucleic-acid-binding domains that includes the APSES, LAGLIDADG endonuclease and TEN domains.
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