Words similar to nucleic-acid-binding
Example sentences for: nucleic-acid-binding
How can you use “nucleic-acid-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
Of these, four subunits, which correspond to the bacterial α, β, β' and ω, are universally present in all cellular DDRPs and constitute the conserved DDRP core [ 7 ] . Orthologs of the β and β' subunits are also encoded in the genomes of several families of large eukaryotic DNA viruses [ 33 34 35 ] . Biochemical studies have shown that the catalytic site of DDRP resides in the β' subunit and contains three invariant aspartates that coordinate a Mg 2+cation [ 22 23 24 36 ] . Recent structural analyses demonstrated that the core of DDRP is assembled around the β and β' subunits, which interact with each other to form a positively charged nucleic-acid-binding cleft.
The Zn-ribbons are widespread, small domains that are comprised of two β-hairpins bounded by consecutive extended regions stabilized by metal-coordinating residues in the hairpin loops [ 67 68 69 70 ] . Zn-ribbons are present in a variety of nucleic-acid-binding proteins, including several ribosomal proteins, translation factors, aminoacyl-tRNA synthetases, RNA polymerase cofactors in archaea and eukaryotes, and several transcription factors.
A potential additional nucleic-acid-binding moiety that is conserved in all β'-subunits is the AT-hook like module (Fig.
At least the former, and perhaps even the latter, appear to belong to a large class of nucleic-acid-binding domains that includes the APSES, LAGLIDADG endonuclease and TEN domains.
Based on the crystal structure, it has been proposed that the region containing the Zn ribbon may interact with the promoter during transcription initiation in bacteria [ 23 ] . Hence, it is plausible that a nucleic-acid-binding Zn-ribbon had been recruited to the ancestral polymerase core, which consisted of the DPBB domains, and contributed to non-specific interactions with the template.
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