Words similar to nucleic-acid-binding
Example sentences for: nucleic-acid-binding
How can you use “nucleic-acid-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
These observations suggest that the APSES, LAGLIDADG and TEN domains, together with the KilA-N domain, define a novel nucleic-acid-binding fold with a conserved (β 2 α) 2 core (Figure 1b).
Of these, four subunits, which correspond to the bacterial α, β, β' and ω, are universally present in all cellular DDRPs and constitute the conserved DDRP core [ 7 ] . Orthologs of the β and β' subunits are also encoded in the genomes of several families of large eukaryotic DNA viruses [ 33 34 35 ] . Biochemical studies have shown that the catalytic site of DDRP resides in the β' subunit and contains three invariant aspartates that coordinate a Mg 2+cation [ 22 23 24 36 ] . Recent structural analyses demonstrated that the core of DDRP is assembled around the β and β' subunits, which interact with each other to form a positively charged nucleic-acid-binding cleft.
The former is a widespread nucleic-acid-binding domain, whereas the latter functions in a variety of biochemical contexts as a small-molecule-binding and protein-protein interaction domain.
Based on the crystal structure, it has been proposed that the region containing the Zn ribbon may interact with the promoter during transcription initiation in bacteria [ 23 ] . Hence, it is plausible that a nucleic-acid-binding Zn-ribbon had been recruited to the ancestral polymerase core, which consisted of the DPBB domains, and contributed to non-specific interactions with the template.
The Zn-ribbons are widespread, small domains that are comprised of two β-hairpins bounded by consecutive extended regions stabilized by metal-coordinating residues in the hairpin loops [ 67 68 69 70 ] . Zn-ribbons are present in a variety of nucleic-acid-binding proteins, including several ribosomal proteins, translation factors, aminoacyl-tRNA synthetases, RNA polymerase cofactors in archaea and eukaryotes, and several transcription factors.
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