Example sentences for: nucleic-acid-binding

How can you use “nucleic-acid-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The Zn-ribbons are widespread, small domains that are comprised of two β-hairpins bounded by consecutive extended regions stabilized by metal-coordinating residues in the hairpin loops [ 67 68 69 70 ] . Zn-ribbons are present in a variety of nucleic-acid-binding proteins, including several ribosomal proteins, translation factors, aminoacyl-tRNA synthetases, RNA polymerase cofactors in archaea and eukaryotes, and several transcription factors.

  • These observations suggest that the APSES, LAGLIDADG and TEN domains, together with the KilA-N domain, define a novel nucleic-acid-binding fold with a conserved (β 2 α) 2 core (Figure 1b).

  • At least the former, and perhaps even the latter, appear to belong to a large class of nucleic-acid-binding domains that includes the APSES, LAGLIDADG endonuclease and TEN domains.

  • Thus, it appears plausible that these domains evolved from an ancestral nucleic-acid-binding module that, on one hand, gave rise to the nucleases through the acquisition of an amino-terminal helical extension that provided the active site, and on the other hand, diversified into distinct nucleic-acid-binding domains.

  • The former is a widespread nucleic-acid-binding domain, whereas the latter functions in a variety of biochemical contexts as a small-molecule-binding and protein-protein interaction domain.


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