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Example sentences for: npy

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Hypothalamic NPY mRNA exhibited a trend toward an increase although the effect was not significant (p = 0.14; Fig.
Adrenalectomy has been reported to block elevations in NPY mRNA in response to fasting [ 14 ] . On the other hand, it has been reported that elevation of plasma corticosterone levels is not required for the induction of NPY mRNA by fasting [ 15 ] . In addition, the extent to which hypothalamic AGRP and POMC mRNA depends on elevated glucocorticoid levels in fasting and insulin deficiency has not been determined to date.
Adrenalectomy also blocked the effects of fasting on hypothalamic NPY mRNA (Fig.
Glucocorticoids have previously been reported to increase body weight set point, as determined by hoarding behavior in rats [ 11 ] , while adrenalectomy has been reported to lower body weight set point in rats [ 12 ] . In addition, central infusion of glucocorticoids leads to increases in body weight and food intake with a concomitant induction of hypothalamic NPY [ 13 ] . Nevertheless, it remains unclear if an elevation in glucocorticoid concentration contributes to the effect of fasting on hypothalamic gene expression.
As with AGRP mRNA, NPY mRNA was elevated in diabetic mice, and adrenalectomy blocked this induction of NPY mRNA in diabetic mice whether or not they were fasted (Fig.