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Example sentences for: npy

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Hypothalamic NPY mRNA exhibited a trend toward an increase although the effect was not significant (p = 0.14; Fig.
Glucocorticoids have previously been reported to increase body weight set point, as determined by hoarding behavior in rats [ 11 ] , while adrenalectomy has been reported to lower body weight set point in rats [ 12 ] . In addition, central infusion of glucocorticoids leads to increases in body weight and food intake with a concomitant induction of hypothalamic NPY [ 13 ] . Nevertheless, it remains unclear if an elevation in glucocorticoid concentration contributes to the effect of fasting on hypothalamic gene expression.
Five micrograms of total RNA from hypothalamus was subjected to Northern blot analysis, as described previously, to measure POMC, AGRP and NPY mRNA [ 3 4 5 9 ] . Seven micrograms of total RNA from adipose tissue was also subjected to Northern blot analysis to measure leptin mRNA.
differed from those in the present paper: adrenalectomy failed to block the effects of fasting on hypothalamic AGRP and NPY, even though corticosterone implants were observed to induce AGRP mRNA.
In turn, as with fasting, the reduction of plasma leptin could be the cause of the elevation of hypothalamic AGRP and NPY mRNA, as well as the reduction of hypothalamic POMC mRNA.