Example sentences for: npy
How can you use “npy” in a sentence? Here are some example sentences to help you improve your vocabulary:
In turn, as with fasting, the reduction of plasma leptin could be the cause of the elevation of hypothalamic AGRP and NPY mRNA, as well as the reduction of hypothalamic POMC mRNA.
Glucocorticoids have previously been reported to increase body weight set point, as determined by hoarding behavior in rats [ 11 ] , while adrenalectomy has been reported to lower body weight set point in rats [ 12 ] . In addition, central infusion of glucocorticoids leads to increases in body weight and food intake with a concomitant induction of hypothalamic NPY [ 13 ] . Nevertheless, it remains unclear if an elevation in glucocorticoid concentration contributes to the effect of fasting on hypothalamic gene expression.
Five micrograms of total RNA from hypothalamus was subjected to Northern blot analysis, as described previously, to measure POMC, AGRP and NPY mRNA [ 3 4 5 9 ] . Seven micrograms of total RNA from adipose tissue was also subjected to Northern blot analysis to measure leptin mRNA.
Adrenalectomy has been reported to block elevations in NPY mRNA in response to fasting [ 14 ] . On the other hand, it has been reported that elevation of plasma corticosterone levels is not required for the induction of NPY mRNA by fasting [ 15 ] . In addition, the extent to which hypothalamic AGRP and POMC mRNA depends on elevated glucocorticoid levels in fasting and insulin deficiency has not been determined to date.
In summary, hypothalamic AGRP, POMC and NPY mRNA all exhibited the expected changes in association with streptozotocin-induced diabetes [ 5 17 ] (Fig.
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