Words similar to non-conserved
Example sentences for: non-conserved
How can you use “non-conserved” in a sentence? Here are some example sentences to help you improve your vocabulary:
CASP1 was an eye-opener in terms of understanding the difficulty of making accurate predictions on approximate templates in comparative modelling [ 14 ] . The main problems in creating a good comparative or fold recognition model were related to alignment between the template and target sequences, and building of non-conserved variable regions (side chains, and main chain loops).
One is the cluster of basic residues KKKKRR (residues 768-773), located in a relatively non-conserved region of the AAA domain between AAA3 and AAA4.
Alignment of this sequence (amino acids 39 to 74) with the central conserved residues of motif I: A--GWEK---E---LK--L------------R--H-D (-- indicating non-conserved residues) shows a good match of identical and conserved amino acid residues: A--GFEK---D---LK--I---------R--H-E.
While the graph-theory methods have been fairly successful at handling the interconnectedness problem to build non-conserved side chains and main chains [ 24 ] , other major problems preventing the construction of accurate comparative models have to do with inaccurate alignments and using the template structure as a static model upon which to build variable main chains.
Variations at residues alpha4 Thr183 and beta2 Ala135 generate different shapes of the binding pocket (Figure 4- Top), but preserve the electrostatic potential of the system: all non-conserved residues at position 183 are hydrophobic, and hydroxyl of Thr154 and Ser154 are superimposed, pointing away from the ligand, towards the carboxylate of Asp122.
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