Words similar to non-conserved

Example sentences for: non-conserved

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CASP1 was an eye-opener in terms of understanding the difficulty of making accurate predictions on approximate templates in comparative modelling [ 14 ] . The main problems in creating a good comparative or fold recognition model were related to alignment between the template and target sequences, and building of non-conserved variable regions (side chains, and main chain loops).
We eliminated those that contained more than four additional non-conserved positions in the non-miRNA-encoding arm compared to within the loop (Figure 2a, class 6), leaving behind class 3 candidates as potential miRNAs.
While the graph-theory methods have been fairly successful at handling the interconnectedness problem to build non-conserved side chains and main chains [ 24 ] , other major problems preventing the construction of accurate comparative models have to do with inaccurate alignments and using the template structure as a static model upon which to build variable main chains.
Variations at residues alpha4 Thr183 and beta2 Ala135 generate different shapes of the binding pocket (Figure 4- Top), but preserve the electrostatic potential of the system: all non-conserved residues at position 183 are hydrophobic, and hydroxyl of Thr154 and Ser154 are superimposed, pointing away from the ligand, towards the carboxylate of Asp122.
One is the cluster of basic residues KKKKRR (residues 768-773), located in a relatively non-conserved region of the AAA domain between AAA3 and AAA4.