Words similar to non-conservative
Example sentences for: non-conservative
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This makes it harder to determine which methods work well and places an inherent penalty on trying different non-conservative approaches.
The recE gene product of the Rac prophage converts dsDNA ends into 3' protruding single-stranded form and the recT gene product promotes recombination by annealing them with a homologous DNA in its vicinity (for review, see [ 7 8 ] ). This recombination may result in one progeny DNA (non-conservative recombination) or two progeny DNAs (conservative double-strand break repair) [ 9 ] . In a recBC sbcBC background, a ds end stimulates homologous recombination that results in only one progeny DNA (non-conservative recombination) [ 10 ] . Analysis of the stimulation of recombination by replication (for review, see [ 11 ] ) and analysis of altered chromosomal replication (for review, see [ 12 ] ) led to the proposal that a chromosomal ds break formed during replication fork arrest triggers homologous recombination, which would reconstitute a replication fork (for review, see [ 5 ] ).
The mammalian sequences are highly conserved, with only 6 non-conservative residue variations between the human and murine sequences, 5 of which occur in the apparently unstructured N-terminus.
These analyses revealed 10 common and 2 rare SNPs [ 19, 20] that alter an amino acid codon; 7 result in non-conservative amino acids changes (Table 3).
This is expected because RecF-mediated recombination is non-conservative in the sense that it generates only one progeny DNA molecule from two parental DNA molecules [ 10 ] . Alternatively, RecF function may somehow help generation of broken chromosomes or maintenance of break to load RecA [ 23 ] .