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Example sentences for: nmj
How can you use “nmj” in a sentence? Here are some example sentences to help you improve your vocabulary:
PKCβ was shown to localize to the presynaptic terminals of NMJs [ 22 23 ] , whereas PKCθ plays a postsynaptic role at the NMJ [ 24 ] . In skeletal muscle, PKCα was found in human muscle fibers [ 25 ] and with T-tubules in rabbit skeletal muscle [ 26 ] . However, it is unknown whether tethering to a PKC-anchoring protein mediates the localization to these compartments.
PKC has been suggested to play a role in synapse stability and signal transduction at the NMJ [ 24 ] . When calcium influx through the nAChR occurs, acetylcholine appears to activate PKC phosphorylation of this receptor [reviewed by [ 31 ] ]. Phorbol ester activation of PKC causes loss of synapses and nAChR [ 49 ] . Because the presynaptic PKCβ fluorescence band parallels the nAChR band (see fig.
The labeling pattern of D-AKAP2 is diffuse in the NMJ, yet localized to the actin region in muscle.
We also investigated the distribution of gravin at the NMJ because this AKAP is an autoantigen for myasthenia gravis, a degenerative disease of the NMJ.
The following files are available with the online version of this article: the e-values of the best matches for the initial BLASTX searches against bacteria, C. elegans and Drosophila for the WMi dataset (Additional data file 1), together with a mapping file (Additional data file 2) that gives the MI contig number associated with each filename; the best match and e-value for the BLASTX search of the WMj dataset against bacteria (Additional data file 3), C. elegans (Additional data file 4) and Drosophila (Additional data file 5); the e-value for the best match to bacteria, C. elegans and Drosophila resulting from a TBLASTX search for the NMi dataset (Additional data file 6), the NMj dataset (Additional data file 7), the NMh dataset (Additional data file 8), where a value of 100 indicates no match found; a text file with details of the data given in each of these dataset files (Additional data file 9); the alignment in Phylip format used to calculate the NodL tree (Additional data file 10); the alignment in Phylip format of the original sequences, before any manual adjustments were made (Additional data file 11); and a key giving the gi number listed in the alignment for each species (Additional data file 12).
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