Example sentences for: nnbc
How can you use “nnbc” in a sentence? Here are some example sentences to help you improve your vocabulary:
plasminogen activator inhibitor-1), after further randomized studies have been conducted, to confirm whether NNBC patients should receive adjuvant systemic therapy [ 47 48 49 ] .
The first study to mention possible prognostic importance of HER-2 / neu gene amplification was reported in 1987 by Slamon et al . [ 27 ] . That study included 187 patients with NNBC and node-positive breast cancer; by univariate and multivariate analyses, it revealed that HER-2 / neu amplification correlated very closely with shorter DFS and OS in a subgroup of 87 node-positive patients.
General details for the double differential PCR technique, reproducibility and clinical significance were described previously [ 17 18 28 40 ] . A cutoff point of more than 2.0 average gene copy number (AGCN) was considered to be positive for HER-2 / neu amplification [ 40 ] . To calculate the cutoff point for c- myc amplification, all NNBC patients were subjected to Classification and Regression Trees (CART) analysis.
Although deregulated HER-2 / neu activity can strongly stimulate cytoplasmic signalling pathways, which in turn impinge on c- myc at multiple levels causing its deregulated expression [ 46 ] , this scenario does not appear to be active in NNBC because the recurrence rate of 22 c- myc and HER-2 / neu coamplified patients was only 9%.
AGCN = average gene copy number; CART = Classification and Regression Trees; CMF = cyclophosphamide, methotrexate, 5-fluorouracil; DFS = disease-free survival; NNBC = node-negative breast cancer; FEC = fluorouracil, epirubicin, cyclophosphamide; OS = overall survival; PCR = poly-merase chain reaction.
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