Example sentences for: nnbc
How can you use “nnbc” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although deregulated HER-2 / neu activity can strongly stimulate cytoplasmic signalling pathways, which in turn impinge on c- myc at multiple levels causing its deregulated expression [ 46 ] , this scenario does not appear to be active in NNBC because the recurrence rate of 22 c- myc and HER-2 / neu coamplified patients was only 9%.
Regarding various adjuvant systemic therapies, such as chemotherapy (CMF, FEC) and endocrine therapy (tamoxifen), no significant differences were observed with respect to DFS and OS in c- myc -amplified and HER-2 / neu -amplified NNBC patients in comparison with non-amplified patients.
Prognostic factors such as tumour size, tumour grading, hormone receptor status, age, histology, ploidy and proliferation index are used to define subgroups of high-risk NNBC patients [ 1 2 3 4 5 6 7 8 ] . Despite the availability of these prognostic markers, high-risk NNBC patients cannot be identified with sufficient accuracy.
Furthermore we studied whether adjuvant therapies such as chemotherapy and endocrine treatment or no treatment at all had any impact on DFS and OS among oncogene-amplified NNBC patients [ 1 2 3 8 9 32 35 36 37 38 ] .
Some studies claimed that HER-2 / neu status was an independent predictive factor in the case of breast cancer, whereas other studies could not confirm this [ 6 14 16 19 29 30 ] . It is certainly of great interest to the clinician that only two out of five studies including more than 100 patients and with a follow-up period of at least 3 years attributed some prognostic value to HER-2 / neu amplification among patients with NNBC [ 6 7 16 19 28 ] . Almost all of the studies that dealt with HER-2 / neu status and DFS, as well as OS, showed no benefit of this oncogene in the prognosis of NNBC patients.
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