Words similar to nnbc

Example sentences for: nnbc

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Among 181 NNBC patients who had undergone breast-conserving therapy or modified mastectomy combined with axillary lymphadenectomy of level 1 and 2 (at least 10 lymph nodes per patient had been removed), c- myc and HER-2 / neu oncogenes were assessed prospectively using double differential PCR.
No corresponding associations were found among HER-2 / neu -amplified NNBC patients as compared with nonamplified patients (Tables 3and 4).
Although deregulated HER-2 / neu activity can strongly stimulate cytoplasmic signalling pathways, which in turn impinge on c- myc at multiple levels causing its deregulated expression [ 46 ] , this scenario does not appear to be active in NNBC because the recurrence rate of 22 c- myc and HER-2 / neu coamplified patients was only 9%.
Regarding various adjuvant systemic therapies, such as chemotherapy (CMF, FEC) and endocrine therapy (tamoxifen), no significant differences were observed with respect to DFS and OS in c- myc -amplified and HER-2 / neu -amplified NNBC patients in comparison with non-amplified patients.
AGCN = average gene copy number; CART = Classification and Regression Trees; CMF = cyclophosphamide, methotrexate, 5-fluorouracil; DFS = disease-free survival; NNBC = node-negative breast cancer; FEC = fluorouracil, epirubicin, cyclophosphamide; OS = overall survival; PCR = poly-merase chain reaction.