Words similar to nnbc

Example sentences for: nnbc

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The advantage conferred by adjuvant chemotherapy or endocrine therapy was examined in randomized studies [ 2 3 8 9 35 36 37 38 ] . Because adjuvant therapies may positively impact on outcome in only around 15%, the costs of these therapies make their routine application in all NNBC patients inappropriate [ 1 ] . For this reason, predictive factors that accurately define subgroups of NNBC patients who may benefit from adjuvant systemic therapy would be a great advantage.
The fact of the matter is that even among NNBC patients 25-30% can be expected to progress or even die.
As in the present investigation, Roux-Dosseto et al . [ 26 ] found that c- myc amplification among NNBC patients was significantly associated with earlier recurrence in univariate and multivariate analyses.
The first study to mention possible prognostic importance of HER-2 / neu gene amplification was reported in 1987 by Slamon et al . [ 27 ] . That study included 187 patients with NNBC and node-positive breast cancer; by univariate and multivariate analyses, it revealed that HER-2 / neu amplification correlated very closely with shorter DFS and OS in a subgroup of 87 node-positive patients.
Furthermore we studied whether adjuvant therapies such as chemotherapy and endocrine treatment or no treatment at all had any impact on DFS and OS among oncogene-amplified NNBC patients [ 1 2 3 8 9 32 35 36 37 38 ] .