Example sentences for: nnbc
How can you use “nnbc” in a sentence? Here are some example sentences to help you improve your vocabulary:
C- myc -amplified NNBC patients who were not administered adjuvant systemic therapy suffer shorter DFS and OS.
The advantage conferred by adjuvant chemotherapy or endocrine therapy was examined in randomized studies [ 2 3 8 9 35 36 37 38 ] . Because adjuvant therapies may positively impact on outcome in only around 15%, the costs of these therapies make their routine application in all NNBC patients inappropriate [ 1 ] . For this reason, predictive factors that accurately define subgroups of NNBC patients who may benefit from adjuvant systemic therapy would be a great advantage.
As in the present investigation, Roux-Dosseto et al . [ 26 ] found that c- myc amplification among NNBC patients was significantly associated with earlier recurrence in univariate and multivariate analyses.
Among 181 NNBC patients who had undergone breast-conserving therapy or modified mastectomy combined with axillary lymphadenectomy of level 1 and 2 (at least 10 lymph nodes per patient had been removed), c- myc and HER-2 / neu oncogenes were assessed prospectively using double differential PCR.
General details for the double differential PCR technique, reproducibility and clinical significance were described previously [ 17 18 28 40 ] . A cutoff point of more than 2.0 average gene copy number (AGCN) was considered to be positive for HER-2 / neu amplification [ 40 ] . To calculate the cutoff point for c- myc amplification, all NNBC patients were subjected to Classification and Regression Trees (CART) analysis.
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