Example sentences for: niii

How can you use “niii” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although several distinct CFEOM phenotypes have been defined [ 6 7 8 ] , each likely resulting from maldevelopment of a unique combination of alpha motor neurons in nIII and/or nIV, most reports of CFEOM families describe a stereotypical clinical phenotype.

  • This study revealed absence of the superior division of the oculomotor nerve and the corresponding central caudal and medial nIII subnuclei, and marked abnormalities of the levator palpebrae superioris and superior rectus muscles [ 4 ] . These findings suggest that while ARIX is necessary for both nIII and nIV development, the CFEOM1 genes may be necessary for the development of only these two specific nIII subnuclei.

  • ARIX, which encodes a transcription factor critical to nIII and nIV development in mice and zebrafish [ 22 23 ] , was recently identified as the FEOM2 gene mutated in affected members of CFEOM2 families [ 5 ] . It was unknown, however, if classic CFEOM may also result from mutations in this gene.

  • Thus far, this phenotype segregates as an autosomal recessive trait and maps to the FEOM2 locus on chromosome 11q13 [ 8 ] , and affected individuals carry homozygous mutations in ARIX [ 5 ] . ARIX encodes a homeodomain transcription factor required for nIII and nIV development in mice and zebrafish [ 22 23 ] . In families with CFEOM3, the CFEOM phenotype is variably expressed.

  • These phenotypes are classified as CFEOM based on the presence of affected members with congenital restrictive ophthalmoplegia affecting extraocular muscles in the nIII/nIV distribution.


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast