Example sentences for: niii
How can you use “niii” in a sentence? Here are some example sentences to help you improve your vocabulary:
ARIX, which encodes a transcription factor critical to nIII and nIV development in mice and zebrafish [ 22 23 ] , was recently identified as the FEOM2 gene mutated in affected members of CFEOM2 families [ 5 ] . It was unknown, however, if classic CFEOM may also result from mutations in this gene.
This finding is consistent with our prediction that, compared to ARIX, the genes mutated in CFEOM1 may have a more restricted function in the development of nIII and that their expression may actually be regulated by ARIX.
Although several distinct CFEOM phenotypes have been defined [ 6 7 8 ] , each likely resulting from maldevelopment of a unique combination of alpha motor neurons in nIII and/or nIV, most reports of CFEOM families describe a stereotypical clinical phenotype.
Thus far, this phenotype segregates as an autosomal recessive trait and maps to the FEOM2 locus on chromosome 11q13 [ 8 ] , and affected individuals carry homozygous mutations in ARIX [ 5 ] . ARIX encodes a homeodomain transcription factor required for nIII and nIV development in mice and zebrafish [ 22 23 ] . In families with CFEOM3, the CFEOM phenotype is variably expressed.
This study revealed absence of the superior division of the oculomotor nerve and the corresponding central caudal and medial nIII subnuclei, and marked abnormalities of the levator palpebrae superioris and superior rectus muscles [ 4 ] . These findings suggest that while ARIX is necessary for both nIII and nIV development, the CFEOM1 genes may be necessary for the development of only these two specific nIII subnuclei.
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