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Example sentences for: nachr
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The alignment was generated automatically by the ICM method and adjusted manually around residues 188-208, to align an insertion in human nAChR subunits with a loop region of the 3D template (Figure 1).
A nAChR is composed of five polypeptide subunits (Figure 1), but there are many nAChR subtypes made of different subunit combinations, a diversity that helps explain why nicotine can have so many different physiological and cognitive effects.
The AChBP displays a large amount of homology to the amino terminal of LGIC receptors and thus may be similar in structure [ 20 24 ] . The crystal structure of this protein reveals a loose 3 residue turn incorporating the conserved glycine residue [ 24 ] . Homologous residues in other LGIC subunits have also been identified and are shown in Figure 1. The residues identified in this study as altering binding affinity of 5-HT 3 R ligands would also be present on the same surface if this structure is present in the 5-HT 3 R. While Y140 lies somewhat outside the region identified by Chiara in the nAChR (homologous to γN107), γL109 and γL119 are homologous to Y142 and Y152 of the 5-HT 3AS R. The ability of lerisetron to interact with both Y142 and Y152 also supports the hypothesis that these two amino acids are present in a loop structure since the eight intervening residues would position Y142 and Y152 too far apart to permit them both to interact with a single ligand even if they were interacting with functional groups on opposite ends of the molecule.
We found that D-AKAP1 appears to colocalize with RIα at the postsynaptic membrane of the NMJ, which houses the nAChR, but not in the presynaptic region.
We also used the monoclonal antibody α-ALS (mab D4) and a polyclonal serum α-Dα2, both directed against α-like ligand-binding subunits of the Drosophila nAChR [ 25, 28].
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