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Example sentences for: nachr
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The AChBP displays a large amount of homology to the amino terminal of LGIC receptors and thus may be similar in structure [ 20 24 ] . The crystal structure of this protein reveals a loose 3 residue turn incorporating the conserved glycine residue [ 24 ] . Homologous residues in other LGIC subunits have also been identified and are shown in Figure 1. The residues identified in this study as altering binding affinity of 5-HT 3 R ligands would also be present on the same surface if this structure is present in the 5-HT 3 R. While Y140 lies somewhat outside the region identified by Chiara in the nAChR (homologous to γN107), γL109 and γL119 are homologous to Y142 and Y152 of the 5-HT 3AS R. The ability of lerisetron to interact with both Y142 and Y152 also supports the hypothesis that these two amino acids are present in a loop structure since the eight intervening residues would position Y142 and Y152 too far apart to permit them both to interact with a single ligand even if they were interacting with functional groups on opposite ends of the molecule.
Alternatively, immunoreactivity of nAChR was labeled with a N,N'-biscarboxypentyl-5,5'-disulfonatoindodicarbocyanine (Cy5) coupled fluorescent secondary antibody.
The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that mediates neurotransmission at the neuromuscular junction, autonomic ganglia and at some sites in the central nervous system.
This observation is supported by previous work that demonstrated RIα codistribution with nAChR [ 19 ] and D-AKAP1 [ 17 ] suggesting that this AKAP is the anchoring protein recruiting RIα to this membrane.
nAChR - nicotinic acetylcholine receptor
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