Words similar to nachr

Example sentences for: nachr

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have suggested that the highly conserved nature of the glycine in this region may indicate the existence of a loop structure consisting of either γ or a loose three residue-turn in the nAChR [ 12 ] . Either of these turns would bring the two putative β-strands together such that γL109, γY111 and γS115 and γY117 are all on the same side of an antiparallel β-sheet.
Previous reports have shown on other systems that a single-residue mutation in a receptor is sufficient for the development of specific ligands [ 13 14 ] . Based on the recent crystal structure of AChBP, we could propose a detailed description of the structural variations of nAChR subtypes.
The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that mediates neurotransmission at the neuromuscular junction, autonomic ganglia and at some sites in the central nervous system.
Table 1shows that binding energy differences between the two ligands and the four nAChR subtypes are rather small, and within the 2.5 kcal/mol accuracy of the estimates [ 20 ] . As expected, no Van der Waals clash is observed.
A disulfide bridge (the so-called cys-loop), present only in the alpha subunits of nAChR, is known to be part of the agonist binding site of the receptor [ 7 ] . This was a clear indication that, in order to build a dimer interface that includes the ligand binding pocket, alpha subunits had to be aligned onto the template monomer presenting a disulfide bridge at the interface (subunit 1).