Words similar to nachr

Example sentences for: nachr

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For instance, nicotine has a Kd of 1 nM for alpha4-beta2 nAChR, but only 4 μM for the alpha7-alpha7 isoform [ 3 ] .
A nAChR is composed of five polypeptide subunits (Figure 1), but there are many nAChR subtypes made of different subunit combinations, a diversity that helps explain why nicotine can have so many different physiological and cognitive effects.
In recent years, it has become clear that the neuronal nAChR is a valid target against a variety of diseases, including cognitive and attention deficits, Parkinson's disease, anxiety, and pain management [ 3 4 ] ; the addiction liability and other undesirable side-effects of nicotine prohibit the use of this natural product for therapeutic applications, but the active development of nAChR agonists presenting adequate receptor subtype specificity should result in improved pharmacology and potency [ 4 ] . As for most membrane proteins, information on the 3 dimensional structure of the nAChR is limited, and the best experimental structure consists of 4.6 A data from electron microscopy [ 5 ] , a resolution that does not allow for structure-based design approaches.
nAChR - nicotinic acetylcholine receptor
The presence of the isotype diversity of nAChR ligand binding pocket should allow for the rational design of selective agonists.