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Example sentences for: nachr
How can you use “nachr” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the Drosophila nervous system mab 3D2 produces exactly the same staining pattern as that observed with polyclonal antisera against the ARD nAChR subunit [ 25].
5) suggests that RIIα is concentrated in the postsynaptic vicinity of the NMJ but is not colocalized with the nAChR.
The presence of the isotype diversity of nAChR ligand binding pocket should allow for the rational design of selective agonists.
Mutation of the homologous residue in the GABA A receptor γ-subunit (T142) to serine altered the efficacy of the agonist Flumazenil, converting it to a partial agonist [ 29 ] . In the nAChR, mutation of mouse and rat εP121 to leucine altered both the binding of acetylcholine and the stability of the open state of the channel.
In recent years, it has become clear that the neuronal nAChR is a valid target against a variety of diseases, including cognitive and attention deficits, Parkinson's disease, anxiety, and pain management [ 3 4 ] ; the addiction liability and other undesirable side-effects of nicotine prohibit the use of this natural product for therapeutic applications, but the active development of nAChR agonists presenting adequate receptor subtype specificity should result in improved pharmacology and potency [ 4 ] . As for most membrane proteins, information on the 3 dimensional structure of the nAChR is limited, and the best experimental structure consists of 4.6 A data from electron microscopy [ 5 ] , a resolution that does not allow for structure-based design approaches.
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