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Example sentences for: nachrs
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These profiles were not surrounded by α-ARD immunoreactivity on their side facing away from the lobula plate, suggesting that the main dendrites have a lower density of nAChRs than the higher order branches of the dendrites deeper within the neuropile.
For instance, epibatidine, a drug that is extracted from the skin of an Ecuadorian frog and that acts at nAChRs, has been shown to be 200 times more potent than morphine at blocking pain in animals.
Current animal research is aimed at discovering just where, how, and which classes of nAChRs work against pain, with the aim of developing more selective drugs.
Distinct nAChR subtypes exist that can be stimulated by the neurotransmitter acetylcholine, the natural product nicotine, or by synthetic compounds [ 1 ] . nAChR is the prototype for a protein superfamily that includes the receptors for the excitatory amino acids glutamate and aspartate, the inhibitory amino-acids gamma-aminobutyric acid (GABA) and glycine, as well as the serotonin 5-HT 3 receptor [ 1 ] . Like most ligand-gated ion channels, nAChRs are homo- or hetero-pentameric, each monomer belonging to a pull of 8 alpha- or 3 beta-subunits (alpha 2-9 , beta 2-4 ). While each subunit has four transmembrane domains, the agonist binding sites are located at the subunit interfaces [ 2 ] . Both natural and synthetic ligands can display varied affinity for different receptor subtypes.
In the following we will present immunocytochemical data of antibody staining against nAChRs, GABA receptors and the inhibitory neurotransmitter GABA itself.
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