Example sentences for: nachrs

How can you use “nachrs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Neuregulin, Role and her colleagues have shown, governs the expression of nAChRs in neurons and helps to stabilize the synapses where they are found.

  • Although all nAChRs are activated by nicotine, other drugs could be found or designed that affect only a subset of these receptor types.

  • Although the analgesic effect of drugs that mimic acetylcholine were originally attributed to a different class of receptors, it is now clear that nAChRs play an important role in the control of pain.

  • For instance, epibatidine, a drug that is extracted from the skin of an Ecuadorian frog and that acts at nAChRs, has been shown to be 200 times more potent than morphine at blocking pain in animals.

  • Our models of the nAChRs binding pocket are only predictive, and need to be confirmed experimentally; testing in vitro the activity of ligand candidates, such as 1, derived from the structure of the receptor would constitute an important first step towards the validation of our models as tools for the discovery of novel nAChR agonists.


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