Example sentences for: nes

How can you use “nes” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Not all terms used in the literature (NEs) can actually be found in some kind of database (perhaps because of an author error, or an alternative name for an entity adopted by the community).

  • It is tempting to speculate that, under certain conditions, the mammalian COP1 NES is shielded within the coiled-coil structure and COP1 protein is imported into the nucleus through the RING finger bridged NLS; under other conditions, probably through a conformation change of the coiled-coil domain, the NES is exposed, overwriting the NLS and transporting mammalian COP1 back into the cytoplasm.

  • These results confirmed the identified sequence ( L AN V N L M L E LL ) within the coiled-coil domain of mammalian COP1 as a likely CRM1/exportin specific NES.

  • In fact, Hurt and coworkers have recently demonstrated the in vitro assembly of a Nup subcomplex from entirely recombinant proteins [ 20 ] . Given the structural and functional similarities between vertebrate and yeast NPCs and the insertion of both into a pre-existing NEs, it is likely that NPC biogenesis occurs via a similar mechanism in all organisms.

  • De novo assembly into intact NEs occurs during cell and nuclear growth to maintain a constant NPC density [ 10 ] . In cells undergoing an open mitosis, NPCs are also re-assembled with the formation of the NE at the end of mitosis [ 11 ] . The mechanisms controlling membrane fusion during pore formation and the steps for assembly of the distinct NPC substructures have not been fully elucidated.


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