Words similar to nes

Example sentences for: nes

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Through systematic mutagenesis studies, we have been able to locate both the NLS and the NES to the N-terminal region of the mammalian COP1 protein (Fig 6and Fig 7).
Interestingly, a sequence ( L AN V N L M L E LL , amino acids 237 to 247), located within the N-terminal region of the coiled-coil domain, matches classic leucine-rich nuclear export signals (NES), such as those from Rex and PKI (Fig 6A) [ 33 34 ] . In order to test if this sequence is a bona fide NES, we made mutations at two conserved leucine residues (L234A and L236A) in the GFP-N200 construct (Fig 6A).
However, treatment with LMB completely shifts GFP-N200 from the cytoplasm to the nucleus, implying GFP-N200 may shuttle between the nucleus and the cytoplasm, consistent with the existence of both the NES and the NLS in GFP-N200 (Fig 6and Fig 7).
In MmCOP1, we have identified a single 10-amino acid classic leucine-rich NES within the corresponding region (Fig 8), even though we have not eliminated the possible involvement of other sequences.
De novo assembly into intact NEs occurs during cell and nuclear growth to maintain a constant NPC density [ 10 ] . In cells undergoing an open mitosis, NPCs are also re-assembled with the formation of the NE at the end of mitosis [ 11 ] . The mechanisms controlling membrane fusion during pore formation and the steps for assembly of the distinct NPC substructures have not been fully elucidated.