Example sentences for: neoplasia

How can you use “neoplasia” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • An association between autocrine IL-6 and PCA has been known for some time [ 16 17 ] . The change in prostate cell phenotype from paracrine IL-6-stimulated to autocrine IL-6-stimulated is believed to be a contributing factor in the progression from benign hyperplasia to neoplasia [ 17 ] . IL-6 is also implicated in the development of cancer cell resistance to chemotherapy in PCA patients [ 18 19 ] . In other studies, a chimeric protein consisting of an anti-IL-6 Ab fused to Pseudomonas exotoxin was found to inhibit proliferation of prostate carcinoma cell lines [ 20 ] . Exogenous IL-6 activated androgen responsive gene expression in the absence of androgens in human LNCaP cells [ 21 ] . More work is needed to clarify the role of IL-6 in prostate neoplasia.

  • While there is some evidence suggesting IL-6-mediated neoplasia in PCA development [ 17 22 ] , a system suitable for following the transformation of prostate cells during PCA development remains lacking.

  • Indeed, since tumor necrosis factor alpha (TNFα) is known to suppress hepatic apoptosis [ 9 ] , a function which is considered a safeguard mechanism against neoplasia [ 10 11 ] , the reported ability of RU486 to elevate hepatic TNFα production in vivo and to enhance cell sensitivity to its toxic effects is alarming [ 12 ] . Glucocorticoids also inhibit hepatocellular proliferation [ 13 14 15 ] and modulate the expression of oncogenes and tumor suppressor genes [ 11 ] , via mechanisms involving the glucocorticoid receptor [ 16 17 18 ] , further supporting the notion that inhibiting these receptors may result in harmful effects.

  • Since it is widely thought that COX-2, more so than COX-1, may play a role in neoplasia, it is reasonable to think that the more effective drugs would be selective for COX-2.

  • Prostate cancer is one of the major diseases that pose serious health problems for aging men [ 1 ] . It is generally believed that androgen has a significant role in the development and progress of this disease [ 2 ] . Changes in the growth response of cancer cells to androgen ablation and anti-androgen during the progress of the disease [ 3 4 5 6 ] suggest that multiple androgen-related signaling events are involved in neoplasia and disease progression.


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