Words similar to neoplasia
Example sentences for: neoplasia
How can you use “neoplasia” in a sentence? Here are some example sentences to help you improve your vocabulary:
This is consistent with current theories of neoplasia, which hypothesize that tumor cells modify their signaling pathways, establish new contacts with an altered extracellular matrix, and refashion their metabolic machinery.
An association between autocrine IL-6 and PCA has been known for some time [ 16 17 ] . The change in prostate cell phenotype from paracrine IL-6-stimulated to autocrine IL-6-stimulated is believed to be a contributing factor in the progression from benign hyperplasia to neoplasia [ 17 ] . IL-6 is also implicated in the development of cancer cell resistance to chemotherapy in PCA patients [ 18 19 ] . In other studies, a chimeric protein consisting of an anti-IL-6 Ab fused to Pseudomonas exotoxin was found to inhibit proliferation of prostate carcinoma cell lines [ 20 ] . Exogenous IL-6 activated androgen responsive gene expression in the absence of androgens in human LNCaP cells [ 21 ] . More work is needed to clarify the role of IL-6 in prostate neoplasia.
Androgen is essential for normal prostate function, but has also been implicated in the pathogenesis and neoplasia of prostate cancer [ 1 2 26 ] . On the other hand, retinoid is essential for normal prostate function [ 7 27 28 ] and exhibits anti-proliferative and chemopreventive efficacy in experimental prostate carcinoma [ 8 9 10 ] . The dose-dependent stimulation of 3H-thymidine incorporation in LNCaP cells by T and RA when administered alone, and reciprocal suppression of such effects by each other, are consistent with previous findings [ 29 30 31 32 ] . These results illustrate interactions between androgen and retinoid in the control of LNCaP cell growth.
Indeed, since tumor necrosis factor alpha (TNFα) is known to suppress hepatic apoptosis [ 9 ] , a function which is considered a safeguard mechanism against neoplasia [ 10 11 ] , the reported ability of RU486 to elevate hepatic TNFα production in vivo and to enhance cell sensitivity to its toxic effects is alarming [ 12 ] . Glucocorticoids also inhibit hepatocellular proliferation [ 13 14 15 ] and modulate the expression of oncogenes and tumor suppressor genes [ 11 ] , via mechanisms involving the glucocorticoid receptor [ 16 17 18 ] , further supporting the notion that inhibiting these receptors may result in harmful effects.
In the study set, eight out of 36 (22%) of the slides showed histologic evidence of hyperplasia, one out of 36 had a ductal carcinoma in situ (mammary intraepithelial neoplasia [ 22]), and one out of 36 had a carcinoma.
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