Words similar to neonatal
Example sentences for: neonatal
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To examine this function in more detail, we employed a culture system that facilitates chondrocyte maturation and cartilage formation, and closely recapitulates the in vivo situation [ 11 ] . The micromass system has been used extensively for studies of cartilage formation from limb mesenchyme [ 10 11 12 13 ] and also for culture of chondrocytes in high density [ 14 ] . Here, we have adapted the system to neonatal mouse rib chondrocytes, to study the role of Hoxc-8 in chondrocyte maturation.
In 24 children with inherited disorders of fatty acid oxidation, conduction defects or arrhythmias were the predominant presenting feature [ 14 ] . Arrhythmias in association with hepatomuscular symptoms and hyperammonemia have also been demonstrated in cases of carnitine-acylcarnitine translocase deficiency whose presenting features also include neonatal distress, convulsions, hypoglycemia, hypoketonemia, intermittent dicarboxylic aciduria, hypothermia, apnea, neurological deterioration, and hypocarnitinemia with grossly elevated acylcarnitines [ 15 ] . The accumulation of arrhythmogenic metabolites of fatty acids, such as long chain acylcarnitines, may be responsible for the observed lethal cardiac defects.
It has recently been shown that primary neonatal cerebellar granule neuron (CGN) precursors proliferate in response to Hh stimulation [ 2 ] . To determine whether the Hh agonist could elicit this response, we monitored [ 3H]-thymidine incorporation of cultured rat CGN precursors treated with Hh protein, Hh-Ag 1.1, Hh-Ag 1.2, or vehicle (DMSO).
[ 3 ] ). In our current experiments, we observed that 1 mM domoic acid did not prime rat neonatal microglia for PMA-stimulated O 2 - release, again in marked contrast with LPS.
Our patient's neonatal presentation and relatively mild clinical course broadens the heterogeneous spectrum of clinical phenotypes associated with altered mitochondrial energy metabolism.
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