Words similar to neonatal
Example sentences for: neonatal
How can you use “neonatal” in a sentence? Here are some example sentences to help you improve your vocabulary:
In summary, in our experiments the in vitro effect of a 1-6 hour exposure to domoic acid on rat neonatal microglia activation and concomitant TNF-α, MMP-9 and O 2 - release was clearly distinct in its magnitude from that observed after exposure to LPS, an agent involved in endotoxic shock and other central nervous pathologies [ 3 ] . Even though this present study was limited to the study of the in vitro effects of domoic acid on three microglia mediators, namely TNF-α, MMP-9 and O 2 -, it provides the first experimental evidence to our knowledge that domoic acid, at in vitro concentrations that are toxic to neuronal cells, can trigger a limited activation of rat neonatal microglia and the concomitant release of modest though statistically significant amounts of TNF-α and MMP-9.
For example, lack of enteral feeding plays an important role in the development of cholestasis in the neonatal period, possibly mediated by direct hepatotoxic activity of bile salts [ 5].
Isolation and culture of rat neonatal microglia
The purpose of this investigation was to determine if a short-term in vitro exposure to domoic acid might activate rat neonatal microglia and cause mediator release.
Briefly, rat neonatal microglia or cerebellar granule cells (60,000 cells / well) were plated in LPS-free 96-well cell culture clusters 24 hours prior to the experiments in either 0.1 ml DMEM supplemented with 10% FBS + 120 U/ml P + 12 μg/ml S (microglia), or 0.1 ml serum-free Neurobasal A medium with B27 supplement (cerebellar granule neurons).
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