Words similar to neonatal
Example sentences for: neonatal
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In summary, in our experiments the in vitro effect of a 1-6 hour exposure to domoic acid on rat neonatal microglia activation and concomitant TNF-α, MMP-9 and O 2 - release was clearly distinct in its magnitude from that observed after exposure to LPS, an agent involved in endotoxic shock and other central nervous pathologies [ 3 ] . Even though this present study was limited to the study of the in vitro effects of domoic acid on three microglia mediators, namely TNF-α, MMP-9 and O 2 -, it provides the first experimental evidence to our knowledge that domoic acid, at in vitro concentrations that are toxic to neuronal cells, can trigger a limited activation of rat neonatal microglia and the concomitant release of modest though statistically significant amounts of TNF-α and MMP-9.
We have recently reported on the kinetics of LPS activation of rat neonatal microglia and the concomitant release of TNF-α protein, MMP-9 and O 2 - [ 7 ] . These three microglia mediators are currently thought to participate in neuronal and glial injury in vivo [ 10 45 ] .
Null mutation of LIFR results in neonatal death and defects in many systems including absence of glial cells, osteoporosis, glycogen hyper-synthesis, placental defects [ 31 ] and loss of motor neuronal subsets that cripple suckling ability [ 32 ] . In all of the systems affected as a biological consequence of LIFR loss, an explanation of the mechanism of action can be designed around direct action of LIFR in each system.
All preterm infants (<35 weeks' gestation) born at St Peter's University Hospital (New Brunswick, NJ, USA) and admitted to the hospital's neonatal intensive care unit between March 1997 and December 1998 were serially screened during the course of hospitalization for entry into the 'cholestasis' study group (Fig.
Upon termination of the experiments, cell-free supernatants from each culture dish were assayed for TNF-α, MMP-2 and MMP-9, while rat neonatal microglia were processed for RNA isolation and RT-PCR.
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