Words similar to nedd

Example sentences for: nedd

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This mutant accumulates Pcu1p exclusively in a form carrying the stimulatory Nedd8p modification, due to a defect in COP9/signalosome-mediated cullin deneddylation [ 24 25 ] . Replacing wild-type ubiquitin by a mutant lacking all lysine residues prevented the formation of high molecular weight products (Fig.
All human cullins interact with HRT1/RBX1/ROC1 [ 7], are modified by NEDD8 [ 8], and have ubiquitin ligase activity in vitro [ 9].
3 also were affected by LOH and exhibited loss of expression in teratoma [ 9 ] . The BTG1 , APAF1 , and NEDD1 genes mapped to the 12q22 common-deletion region, and thus considered as candidate TSGs in GCT [ 8 10 11 ] .
NEDD1 -UF 5'-TGGATATTTTTTAGTTTAGTGTG-3'
While Csn5 is thought to impede the action of ubiquitin ligases through shaving cullins from their Rub1/Nedd8 modification (and possibly also by deubiquitinating substrates bound to the cullins), the outcome of Rpn11 inhibition will depend largely on whether Rpn11 participates primarily in shaving substrates from their chains, promoting release and rescue, or in trimming the polyubiquitin tag, allowing for proteolysis quality control (Figure 2).