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Example sentences for: myosins
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Phylogenetic analysis of Arabidopsis myosins along with other plant myosins suggests that most class XI myosins (except three) fall into two subgroups (Figure 4).
An important aspect of actin cytoskeletal research has been the use of small molecules that affect actin dynamics and proteins that act on the cytoskeleton [ 1 ] . 2,3-butanedione monoxime (BDM) is a small molecule that inhibits the ATPase activity of muscle myosinII and reduces the force generated by this motor protein [ 2 3 ] . BDM was introduced to the cell biology community as a millimolar inhibitor of multiple non-muscle myosins with greatest potency in inhibiting non-muscle myosinII [ 4 ] . It was subsequently used, in concert with other approaches, to study nm-myosinII function in a variety of biological processes [ 5 6 7 8 ] . BDM was recently shown not to inhibit any non-muscle myosins so far tested, leaving the question of how it affects cells unanswered [ 9 10 ] .
Myosins from another alga, Acetabularia cliftonii, are classified into a separate group (XIII) and one myosin each from the fungi Emericella nidulans and Pyricularia grisea are also assigned to a separate class (XVII).
The Arabidopsis myosins have anywhere from three to six IQ domains.
The myosin was cloned and characterized and found to be a class XI myosin related to the Arabidopsis MYA myosins [ 54].