Words similar to muscimol

Example sentences for: muscimol

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Preliminary reports have linked ligands active at the GABA receptor with SB or other NTDs, including benzodiazepines, alcohol, and zinc [ 7 8 9 10 11 ] . Preliminary work from this laboratory has shown the GABAa receptor agonist muscimol and the GABAb agonist baclofen produce both SB and the Arnold-Chiari malformation, commonly associated with SB [ 12 13 14 ] . VA appears to produce most of its anticonvulsant effects by increasing levels of GABA in the CNS, presumably by inhibiting the enzyme GABA-transaminase (GABA-T).
The GABAa agonist muscimol produced a significant widening of the vertebral arch at all three doses tested (1, 2, 4 mg/kg) (p=.
Work in this laboratory has shown lags in neuromuscular development associated with excessive zinc exposure during neural tube formation and, possibly, accompanying narrowing of the vertebral arches [ 26 ] . Another curious finding of this study is that widening of the vertebral arch occurs with either the GABAa agonist muscimol or the antagonist bicuculline.
Muscimol is a well-documented specific and potent GABAa agonist [ 33 ] .
In studies, it has been reported that increases in intracellular Ca +2or decreases in intracellular pH can uncouple cells [ 15 ] . So they suggest that a participation of the GABA receptors in the regulation of Ca +2concentration or intracellular pH could explain the uncoupling effect of muscimol.