Words similar to muscimol

Example sentences for: muscimol

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Preliminary reports have linked ligands active at the GABA receptor with SB or other NTDs, including benzodiazepines, alcohol, and zinc [ 7 8 9 10 11 ] . Preliminary work from this laboratory has shown the GABAa receptor agonist muscimol and the GABAb agonist baclofen produce both SB and the Arnold-Chiari malformation, commonly associated with SB [ 12 13 14 ] . VA appears to produce most of its anticonvulsant effects by increasing levels of GABA in the CNS, presumably by inhibiting the enzyme GABA-transaminase (GABA-T).
Muscimol is a well-documented specific and potent GABAa agonist [ 33 ] .
Work in this laboratory has shown lags in neuromuscular development associated with excessive zinc exposure during neural tube formation and, possibly, accompanying narrowing of the vertebral arches [ 26 ] . Another curious finding of this study is that widening of the vertebral arch occurs with either the GABAa agonist muscimol or the antagonist bicuculline.
While the GABAa agonist muscimol and antagonist bicucullin widened the vertebral arch, as did the GABAb agonist baclofen, the GABAb antagonist hydroxysaclofen narrowed the vertebral arch.
The GABAa agonist muscimol produced a significant widening of the vertebral arch at all three doses tested (1, 2, 4 mg/kg) (p=.