Words similar to muscimol
Example sentences for: muscimol
How can you use “muscimol” in a sentence? Here are some example sentences to help you improve your vocabulary:
Furthermore, muscimol inhibited dye-transfer between neurons in the SCN culture in a dose-dependent fashion, so that GABA might have reduced gap junction communication between SCN neurons via the GABAA receptor [ 14 ] . In that study they could not clarify how the activation of a GABAA receptor and subsequent increase in chloride conductance impact gap junctions.
Work in this laboratory has shown lags in neuromuscular development associated with excessive zinc exposure during neural tube formation and, possibly, accompanying narrowing of the vertebral arches [ 26 ] . Another curious finding of this study is that widening of the vertebral arch occurs with either the GABAa agonist muscimol or the antagonist bicuculline.
Previous work in this laboratory has demonstrated narrowing of the vertebral arch when zinc is co-administered with baclofen or muscimol [ 13 ] . It is unclear what the structural or functional consequence of vertebral arch narrowing is.
While the GABAa agonist muscimol and antagonist bicucullin widened the vertebral arch, as did the GABAb agonist baclofen, the GABAb antagonist hydroxysaclofen narrowed the vertebral arch.
Preliminary reports have linked ligands active at the GABA receptor with SB or other NTDs, including benzodiazepines, alcohol, and zinc [ 7 8 9 10 11 ] . Preliminary work from this laboratory has shown the GABAa receptor agonist muscimol and the GABAb agonist baclofen produce both SB and the Arnold-Chiari malformation, commonly associated with SB [ 12 13 14 ] . VA appears to produce most of its anticonvulsant effects by increasing levels of GABA in the CNS, presumably by inhibiting the enzyme GABA-transaminase (GABA-T).
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