Words similar to muscarinic
Example sentences for: muscarinic
How can you use “muscarinic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Olanzapine is a newer atypical antipsychotic agent with a pharmacological profile very similar to that of clozapine [ 11 ] . In human brain tissue, olanzapine displays very high affinity for the H1 histamine receptor, high affinity for 5-HT2A and 5-HT2C receptors [ 12 ] . In addition it also shows affinity for D2, muscarinic, and alpha1 receptors, with lower affinity for alpha2, 5-HT1D and 5-HT1A receptors (Table 1 [ 12 ] ).
Casciola-Rosen and coworkers have proposed that modifications of autoantigens during cell death, particularly proteolytic cleavage, might be crucial for the generation of autoantibodies in autoimmune diseases [ 23 37 ] . Unique proteolytic fragments of α-fodrin and type 3 muscarinic acetylcholine receptor have been implicated in the generation of autoantibody responses in primary Sjögren's syndrome [ 38 39 ] .
In fact, clozapine has a greater affinity for muscarinic receptors than olanzapine [ 11 ] and clozapine was also able to decrease the EMG and abolish the bursting pattern during phase 2.
Recent in vitro observations that α-synuclein is phosphorylated by G protein-coupled receptor kinases, and that this phosphorylation relieves its inhibitory action on PLD2 [ 40 ] , suggest a novel mechanism by which neurotransmitter receptors (including muscarinic receptors) might modulate PLD2 activity.
Muscarinic blockade was also reported to decrease the EUS EMG in all phases of the bladder contraction [ 33 ] . However, another study showed no effect on the EUS EMG following muscarinic antagonism [ 34 ] . Therefore, the exact role of muscarinic blockade on the activity of the EUS in the rat is unclear.
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