Example sentences for: msh

How can you use “msh” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This site may contain a factor protecting cells from tobacco induced carcinogenesis, including genes such as MSH1, a gene involved in mismatch repair [ 22 ] .

  • For example, at the time of purchase we were unable to acquire sequence-verified IMAGE clones of Prm1, Dmc1, Msh4 and a number of important cyclins, all of which have key roles in testicular function.

  • Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.

  • The hypophagia of diet-induced obesity may be related to the modestly elevated hypothalamic POMC, whose product alpha-MSH is a known anorexic agent [ 20 29 ] . In turn, the induction of hypothalamic POMC by the high-fat diet might have been due in part to the elevation of leptin in diet-induced obese mice (Table I).


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