Words similar to msi
Example sentences for: msi
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Microsatellite instability (MSI) is hallmark of mismatch repair-deficient cancers, which has been observed in all cancers arising from Hereditary Non-polyposis Colorectal Cancer (HNPCC) syndrome, some sporadic colorectal and other cancers [ 38 ] . MSI is generally associated with germ-line mutations in one of two MMR genes, hMLH1 and hMSH2 . Epigenetic inactivation of promoter hypermethylation of APC and HIC1 also results in MSI phenotype in sporadic colorectal cancers [ 39 40 ] . Accumulating evidence supports the view that promoter methylation of mismatch repair genes may be related to MSI phenotype [ 41 42 ] . A number of previous studies have shown the existence of MSI phenotype in CC [ 43 44 ] . In the present study, we found that MSI-H occurs at an increased frequency in tumors with HIC1 and APC promoter hypermethylation.
Methylation status was correlated with clinical and histologic characteristics, and microsatellite instability (MSI).
Although the MSI phenotype also had no significant correlation with overall promoter methylation, the HIC1 (P = 0.02) and APC (P = 0.08) genes were frequently methylated in patients exhibiting MSI-H phenotype (Table 2).
Here we showed that promoter methylation is associated with advanced stage of the disease, RARB and BRCA1 promoter methylation predict a worse prognosis, and the HIC1 and APC promoter methylation is frequently associated with MSI.
Of the 82 primary tumors studied for promoter methylation, 48 tumors were also examined for microsatellite instability (MSI) using 49 di- or tetra-nucleotide markers [ 14 15 16 17 ] . We found 9 of 48 (18.
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