Words similar to morphogenetic
Example sentences for: morphogenetic
How can you use “morphogenetic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The bone morphogenetic proteins (BMP) have been found to be expressed in the fracture callus by immunostaining of the protein [ 1, 2, 3] as well as by measurement of mRNA [ 4, 5] and in situ hybridization [ 6, 7].
The bone morphogenetic proteins (BMPs) form a subfamily of the Transforming Growth Factor β (TGF-β) superfamily [ 1 2 3 4 ] . Members of the BMP family were initially identified by their ability to induce ectopic bone formation [ 4 ] . Functional characterization of BMPs and the cloning of new BMP family members have revealed that BMPs not only regulate bone formation and homeostasis but also function as morphogenetic factors for many other tissues and organs [ 2 ] . The critical regulatory roles of BMPs during early embryogenesis, such as neurogenesis, mesoderm formation and patterning, are also well-recognized [ 1 2 3 ] .
Most notably, the neural-plate explant assay has defined the concentration-dependent role that ventrally expressed Shh plays in opposing dorsally expressed bone morphogenetic proteins (BMPs) to pattern the neural tube [ 2 ] . The assay demonstrates that the Hh-signaling cascade can distinguish between small concentration differences in the Hh ligand to instruct the differentiation of specific neuronal cell types.
It induces neuronal differentiation in retinoblastoma cells, protects retina neurons (including photoreceptors) from death by apoptosis and other insults, and has a morphogenetic effect on photoreceptor cells [ 3 4 5 6 ] . It also has neurotrophic effects on neurons from the cerebellum, hippocampus and spinal cord [ 7 8 9 10 11 12 ] . In the intact retina, this factor is identified as a secreted protein associated by ionic interactions with the interphotoreceptor matrix [ 13 14 ] , where GAGs are the major polyanionic components.
It has been speculated that intra-articular delivery of TGF-β1 would result in enhanced synthesis of new matrix [ 9 ] . Indeed, we have reported previously that the TGF-β1 gene is more effective than insulin-like growth factor type 1 and bone morphogenetic protein type 2 genes in stimulating new matrix synthesis from rabbit chondrocytes in culture.
Loading...