Words similar to monocyte
Example sentences for: monocyte
How can you use “monocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:
CMV = cytomegalovirus, MCMV = murine cytomegalovirus, MCP-1 = monocyte chemoattractant protein-1, PCNA = proliferating cell nuclear antigen, PDGF = platelet derived growth factor, SSc = systemic sclerosis, TGF-β 1 = transforming growth factor-β 1 , TUNEL = terminal TdT-mediated dUTP nick end labeling, α-SMA = α-smooth muscle actin
Tumour necrosis factor-α blockade reduces synovial expression of CCL2 and CXCL8 and reduces inflammatory cell migration into RA joints [ 9 ] . In addition, these chemokines, produced by RA synovial stromal cells, have been shown to stimulate monocyte migration [ 10 ] . The functional importance of chemokines in joint inflammation has also been established in animal models of RA where antibodies to these mediators significantly reduce both the number of leukocytes recruited and the severity of disease.
The monocyte functional studies in vitro demonstrate that 0.5-10 nM levels of the fragment have significant chemotactic activity.
For example, RP L18, which was significantly down-regulated by NGF, has been reported to negatively regulate double-stranded RNA (dsRNA)-activated protein kinase (PKR) [ 45 ] . As an additional example RP S19, which is also down-regulated by NGF, has been implicated in erythropoiesis and has also been described as a monocyte chemotactic factor [ 46 ] . As one last example, rat RP L9 which we found to be up-regulated by NGF starting within a few hours and maximally by 8 hrs, has been shown to be the ortholog of the yeast gene grc5 which appears to be involved in multiple cellular functions including growth control, cytoskeleton control and energy metabolism [ 47 ] . Identification of NGF-regulated RPs should now facilitate exploration of their potential roles in the responses of cells to neurotrophins.
Anti-CCR5 blocking mAb did not effect monocyte migration.
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