Words similar to monocytes
Example sentences for: monocytes
How can you use “monocytes” in a sentence? Here are some example sentences to help you improve your vocabulary:
Others have demonstrated that inactivation of Rho in monocytes promotes cellular adhesion to β1 integrin substrates [ 37 ] . Static cell adhesion studies rely on a number of factors including integrin affinity regulation, integrin avidity/clustering, and shear resistant cell shape changes.
The molecular signals required for osteoclastogenesis have recently been elucidated [ 1 4 5 ] . Receptor-activator of NFκB ligand (RANKL), a tumor necrosis factor superfamily ligand expressed by stromal cells, osteoblasts, and activated T cells, binds to its cognate receptor-activator of NFκB (RANK) receptor on macrophages/monocytes, inducing a signal that gradually transforms the macrophages into osteoclasts over a period of several days [ 6 7 ] . While this interaction occurs largely in the bone microenvironment, it has been shown that monocytes from the spleen, peripheral blood, and synovium are all capable of RANKL-dependent osteoclast formation [ 8 ] . Convincing evidence has been generated indicating that the RANK-RANKL interaction is absolutely required for osteoclastogenesis [ 7 ] ; in the absence of these molecules, osteoclastogenesis cannot occur [ 9 ] .
We reasoned that peripheral blood cells may serve as a surrogate tissue since VEGF receptors are expressed in certain blood cell types such as monocytes and platelets [ 11 12 ] and thus signal transduction in those cells may be directly impacted by SU5416; also, gene expression changes in blood cells caused indirectly as a result of therapy-induced perturbations might also be detected in this approach.
Because of baseline variation in cell populations between batches of primary human monocytes isolated from multiple donors, cell culture experiments were performed in triplicate and data from representative experiments are presented.
The initial fall in leukocyte cell count observed in vivo is in accord with published data [ 34 35 36 ] . The numbers of monocytes and neutrophils dropped within the first hour, by approximately 98% and 76%, respectively, and of lymphocytes, by 80% after 4 hours.
Loading...