Words similar to mitogen
Example sentences for: mitogen
How can you use “mitogen” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since (a) it is generally accepted that CD4 or CD8 are physically associated to the TCR in the course of T cell activation [ 17 18 ] and (b) it is well known that mitogen activated protein (MAP) kinase signaling is involved in the selection of the T cell repertoire [ 19 20 ] , the present study further proposes that the PKC and PKA-mediated signaling, which regulates TCR expression, can coordinately modulate the selection of CD4 +CD8 -and CD4 -CD8 +T cells during human intrathymic differentiation.
To determine if this dramatically decreased EGFR expression could inhibit downstream components of EGF signaling, we also examined activation of ERK1 (a terminal effector in the mitogen activated protein kinase pathway).
We have earlier demonstrated that TGF-β in part mediates the immunosuppressive effects of these drugs [ 11 12 21 22 ] and therefore the increased levels of TGF-β may partially explain the increased inhibition of mitogen induced lymphocyte proliferation.
cPLA 2 is phosphorylated by mitogen activated protein (MAP) kinases, including p42/p44 ERKs and p38, on Ser 505in vitro [ 16 17 ] and in response to receptor stimulation [ 16 18 19 20 21 ] . In addition to phosphorylation by MAP kinase, it has been shown that cPLA 2 is also phosphorylated on Ser 727by MAPK-interacting kinase I (MNKI) [ 22 ] and on Ser 515by calcium/calmodulin-dependent protein kinase II [ 23 ] . Phosphorylation of these sites may also play a role in regulating cPLA 2 function in certain cell models.
The C-terminal C-box (aa 352-399), harboring the transactivation domain, contains several consensus mitogen activated protein kinase (MAPK) phosphorylation sites.
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