Words similar to mitogen
Example sentences for: mitogen
How can you use “mitogen” in a sentence? Here are some example sentences to help you improve your vocabulary:
This was correlated with the induction of total mitogen activated protein (MAP) kinases, as well as NF-κB and cAMP response element binding (CREB) protein transcription factor activity in the cells.
Opioid receptors (ORs), like many other G protein-coupled receptors (GPCRs), are capable of signalling via the family of mitogen activated protein kinases (MAPKs).
To determine if this dramatically decreased EGFR expression could inhibit downstream components of EGF signaling, we also examined activation of ERK1 (a terminal effector in the mitogen activated protein kinase pathway).
Our finding that 24 h exposure to 4-AP decreased the number of viable GC in serum-free but not serum-supplemented primary cultures is consistent with the reported effects of 4-AP and other K +channel antagonists on other cell types [ 8 43 44 ] . It has been shown that the concentrations of K +channel antagonists required to inhibit growth of human bladder tumor cells can be 70 times higher in the presence than the absence of serum [ 43 ] . 4-AP has been shown to inhibit the proliferation of human myelobastic leukemia cells by preventing growth factor activation of mitogen activated protein kinase (MAPK) pathways [ 42 ] . This mechanism may be responsible for the anti-proliferative effect of 4-AP manifest in Table 1. It is likely that MAPK pathways are less robust in GC grown in defined serum-free vs. serum-supplemented media; however, validation of this hypothesis would require additional experiments beyond the scope of the present investigation.
The C-terminal C-box (aa 352-399), harboring the transactivation domain, contains several consensus mitogen activated protein kinase (MAPK) phosphorylation sites.
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