Words similar to midas
Example sentences for: midas
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All the MIDAS sequence motifs in this domain are retained and most of the residues in the highly conserved NH 2 -extension of the M-domain are unaffected.
One possibility is that the MIDAS site serves to attach protein ligands through a mechanism involving participation of a glutamate or aspartate residue on the ligand in the coordination of a Mg 2+ion at the MIDAS site of midasin, in a manner similar to that by which the MIDAS site in integrin I-domains appears to mediate attachment of collagen through the glutamate in the GFOGER binding motif [ 36 ] . Interestingly, the related RGE ligand-binding motif [ 41 ] occurs in a conserved region of the midasin AAA-domain (yeast, residues 1835-1838), as well as in the AAA-domain of Mg chelatases [ 32 ] . The presence of this consensus binding motif in the AAA domain raises the possibility of the midasin molecule folding back onto itself, with the M-domain becoming attached to one face of the AAA domain and perhaps regulating access to its central chamber, in a manner analogous to that in which the 19S proteasome regulator, also an AAA protein, controls access to the central proteolytic chamber of the proteasome [ 42 ] .
At critical points in her life, she chose brilliant and charismatic men to marry (Phil, president of the Harvard Law Review ), hire (Bradlee--well, Bradlee is Bradlee), or go into business with (Buffett, the modern Midas).
The residues in the MIDAS motifs lie on three closely apposed loops located on the upper edge of the β-sheet, where they form the metal-binding site, with oxygen atoms in the aspartate, serine and threonine residues coordinating the metal ion [ 9 ] . In integrin α2β1, which is a collagen receptor, the metal-binding site also binds the collagen ligand through the conserved glutamate in a GFOGER motif (O = hydroxyproline) completing the coordination sphere of the metal [ 28 ] . In vivo, the binding of collagen at this site appears to be regulated through a conformational shift in which the loops forming the MIDAS site change from a closed to an open conformation [ 29 30 31 ] . Other proteins containing a domain with all three MIDAS motifs include the D-subunit of magnesium chelatase [ 32 ] , Ca-activated chloride-channel protein [ 33 34 ] , nitrate reductase (accession AAC79447), and the D subunit of nitric oxide reductase (accession AAC45374).
Rothko's last decade is like some strange twist on the Midas myth.
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